Cumulative mtDNA damage occurs in aging animals, and mtDNA mutations are reported to
accelerate aging in mice. We determined whether aging results in increased DNA oxidative …

OBJECTIVE— We determined whether reduced insulin sensitivity, mitochondrial dysfunction,
and other age-related dysfunctions are inevitable consequences of aging or secondary to …

Gastric cancer (GC) is a highly heterogeneous disease. To identify potential clinically
actionable therapeutic targets that may inform individualized treatment strategies, we performed …

Aging is associated with progressive decline in energetic reserves compromising cardiac
performance and tolerance to injury. Although deviations in mitochondrial functions have been …

… Once a protein or a cluster of proteins is identified, an analysis of the function(s) is important.
Altered function may result from changes in protein concentration or posttranslational …

Obstructive sleep apnea (OSA), the commonest form of sleep-disordered breathing, is
characterized by recurrent episodes of intermittent hypoxia and sleep fragmentation. This study …

… The mass spectrometric analysis consisted of a 1 s survey scan from 400 to 1600 m/ z
and switched to 2 s MS/MS. The fragmentation scan on ions that exceeded a threshold of ten …

Lipopolysaccharide (LPS) is a major structural component of all Gram-negative organisms
and has been implicated in Gram-negative sepsis and septic shock. In the present study, …

BACKGROUND AND PURPOSE: The molecular characteristics of intracranial aneurysms
are still poorly documented. A rabbit elastase aneurysm model has been helpful in the …

BACKGROUND AND PURPOSE: The molecular characteristics of the pathophysiology of
saccular aneurysms remain poorly understood. The purpose of the current study was to …