… Jude’s have shown that outcomes for average/standard-risk medulloblastoma exceed 80
% 5-year survival [13, 26, 36]. Most non-metastatic SHH patients fall into this category with the …

Medulloblastoma (MB) comprises a biologically heterogeneous group of embryonal tumours
of the cerebellum. Four subgroups of MB have been described (WNT, sonic hedgehog (…

Heritable predisposition is an important cause of cancer in children and adolescents.
Although a large number of cancer predisposition genes and their associated syndromes and …

Accurate pathological diagnosis is crucial for optimal management of patients with cancer.
For the approximately 100 known tumour types of the central nervous system, standardization …

Medulloblastoma, a small blue cell malignancy of the cerebellum, is a major cause of morbidity
and mortality in pediatric oncology. Current mechanisms for clinical prognostication and …

Pan-cancer analyses that examine commonalities and differences among various cancer
types have emerged as a powerful way to obtain novel insights into cancer biology. Here we …

Medulloblastoma is the most common malignant brain tumor in childhood. Molecular studies
from several groups around the world demonstrated that medulloblastoma is not one …

Ependymal tumors across age groups are currently classified and graded solely by histopathology.
It is, however, commonly accepted that this classification scheme has limited clinical …

… 7.06 × 10 −6 , two-tailed Fisher’s exact test with a Bonferroni correction), and these mutations
… This study included samples provided by the UK Children’s Cancer and Leukaemia Group (…

Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly
aggressive, poorly differentiated embryonal tumors occurring predominantly in young children …