… at the RBD of the S protein 74 . Generally, the RBD in the S protein of a CoV interacts with the
… S1 unit of the S protein implicates that the binding affinity of its S protein with human ACE2 …

… Assuming the displacements of the ligand terminals in the transition states are equal in the
two scenarios (d s = d l ), the short and rigid ligand would be bent to a larger angle (θ s > θ l ). …

Metal-organic frameworks (MOFs) are a fascinating class of highly porous materials composed
of metal ions/clusters and organic linkers, which promise great potential in numerous …

… Reactions were incubated at 50C for 10 min and 95C for 2 min, followed by 45 cycles at 95C
for 5 s and 60C for 30 s, and then subjected to melting curve analysis (95C for 5 s, 65C for 1 …

Severe acute respiratory syndrome coronavirus (SARS-CoV) is capable of inducing a storm
of proinflammatory cytokines. In this study, we show that the SARS-CoV open reading frame …

… However, the external subdomain of Spike’s receptor binding domain of 2019-nCoV shares
only 40% amino acid identity with other SARS-related coronaviruses. Remarkably, its orf3b …

… reveals decreased S 1 /S 2 cleavage … S 1 /S 2 cleavage facilitates the exposure of the S 2
′ cleavage site upon receptor binding that is required for TMPRSS2-mediated cleavage at S 2 …

… Cells were split after 4 days and maturated for 6 more days or further induced to differentiate
based on an adapted alveolar differentiation protocol 67 in Iscove’s modified Dulbecco’s …

… Weight losses were compared using 2-way ANOVA and Student’s t test was used to determine
significant differences in virus titers between the different groups [16]. A P value less than .…

… We incubated the reactions at 45C for 10 min for reverse transcription, 95C for 5 min for
denaturation, followed by 45 cycles of 95C for 5 s and 55C for 30 s. We detected and measured …