I n the United States there are 28,000 to 30,300 newly diagnosed cases of pancreatic cancer
and approximately an equal number of deaths per year from pancreatic cancer. 1, 2 Ductal …

… Pisharath H, Rhee JM, Swanson MA, Leach SD, Parsons MJ. Targeted ablation of beta cells
… Provost E, Rhee J, Leach SD. Viral 2A peptides allow expression of multiple proteins from a …

… Liu & SD Leach, unpublished data). In this model, the hybrid transcriptional activator Gal4-VP16
is driven by the Ptf1a promoter through BAC recombineering, whereas the fusion eGFP-…

The availability of human genome sequence has transformed biomedical research over the
past decade. However, an equivalent map for the human proteome with direct …

There are currently few therapeutic options for patients with pancreatic cancer, and new
insights into the pathogenesis of this lethal disease are urgently needed. Toward this end, we …

Metastasis is the leading cause of cancer-associated death but has been difficult to study
because it involves a series of rare, stochastic events. To capture these events, we developed …

Pancreatic cancer is one of the most lethal malignancies due to its late diagnosis and limited
response to treatment. Tractable methods to identify and interrogate pathways involved in …

Notch signaling regulates cell fate decisions in a wide variety of adult and embryonic tissues.
Here we show that Notch pathway components and Notch target genes are upregulated in …

Purpose: Effective new markers of pancreatic carcinoma are urgently needed. In a previous
analysis of gene expression in pancreatic adenocarcinoma using serial analysis of gene …

Objective Tumor invasion of the superior mesenteric-portal vein (SMPV) confluence is often
considered a contraindication to pancreaticoduodenectomy for patients with malignant …