Background Recurrent medulloblastoma is a therapeutic challenge because it is almost
always fatal. Studies have confirmed that medulloblastoma consists of at least four distinct …

Telomerase reverse transcriptase (TERT) promoter mutations were recently shown to drive
telomerase activity in various cancer types, including medulloblastoma. However, the clinical …

Loss-of-function of alpha thalassemia/mental retardation syndrome X-linked (ATRX) protein
leads to a phenotype called alternative lengthening of telomeres (ALT) in some tumors. High-…

Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Dysregulation
of WNT signaling occurs in up to 20% of cases. Using a genome-wide approach, we …

… Croul, MD, 41 Michal Zapotocky, MD, PhD, 42 Cynthia Hawkins, MD, PhD, 43 Uri Tabori,
MD, 43 Michael D. Taylor, MD, PhD, 43 Stefan M. Pfister, MD, 27 Paul Klimo, Jr, MD, 44 …

High‐grade astrocytomas ( HGAs ), corresponding to W orld H ealth O rganization grades III
(anaplastic astrocytoma) and IV (glioblastoma; GBM ), are biologically aggressive, and their …

Thrombospondin-1 is a multifunctional protein interacting with several cell surface receptors
including integrins. We found that it is a ligand for α9β1 integrin, and has an integrin binding …

Poly(ADP-ribose) polymerase (PARP) is thought to play a physiological role in maintaining
genomic integrity and in the repair of DNA strand breaks. However, the activation of PARP by …

This article constitutes a mini-review of the pathology and genetics of meningiomas. Meningiomas
are the most common primary intracranial tumors. They are usually durally based and …

Medulloblastoma (MB) is a malignant cerebellar tumor that occurs primarily in children. The
hepatocyte growth factor (HGF)/MET pathway has an established role in both normal …