… Hopkins University School of Medicine (Drs Crum, Bassett, and Folstein), Baltimore, Md. …
Furthermore, Bassett and Folstein53 showed that loweducation individuals with low MMSE …

Elevated hippocampal activation is observed in conditions that confer risk for Alzheimer's
disease, including amnestic mild cognitive impairment (aMCI). Studies in relevant animal …

Alpha-2-macroglobulin (α-2 M; encoded by the gene A2M) is a serum pan-protease inhibitor
that has been implicated in Alzheimer disease (AD) based on its ability to mediate the …

Objective: To explore the impact of apoE-4 on Alzheimer's disease (AD) and its age at onset.
Design: A genetic linkage study using affected relative pairs, predominantly siblings. Setting…

… ), Massachusetts General Hospital and Harvard Medical School, Boston; the Department
of Psychiatry, The Johns Hopkins University Medical institutions, Baltimore, Md (Drs Bassett …

Alzheimer's disease (AD) is a devastating neurodegenerative disorder of late life with
complex inheritance. Mutations in three known genes lead to the rare early-onset autosomal …

Background Ornithine transcarbamylase is an X-linked mitochondrial enzyme that catalyzes
the synthesis of citrulline from carbamoyl phosphate and ornithine. A deficiency of this …

In patients with Parkinson disease (PD), impulse control disorders (ICDs) such as
hypersexuality and pathologic gambling and shopping can be devastating complications of …

This study examined the prevalence of memory complaint and poor memory performance on
brief screening measures within a community sample of 810 adults. All individuals received …

Alzheimer's disease poses a looming crisis for the health care system as well as society in
general. The low efficacy of current treatments for those already affected with this disease has …