4fi-Imidazo [2, lc][l, 4] benzoxazine-2-carboxylic acid (3) was found to possess potent activity
in the IgE-induced rat passive cutaneous anaphylaxis model which may be predictive of …

The active metabolite (2) of the novel immunosuppressive agent leflunomide (1) has been
shown to inhibit the enzyme dihydroorotate dehydrogenase (DHODH). This enzyme catalyzes …

Several series of heterocyclic carboxylic esters were found to be active in the benzodiazepine
receptor binding assay, a typical example being ethyl 7-ethyl-5-methoxyimidazo [l, 2-o] …

The antiallergic activity of some xanthone derivatives containing a sulfoximide substituent
has been investigated. While 2-(S-methylsulfonimidoyl) xanthone itself was found to be …

In a survey of 5675 patients presenting to five hospitals in England, Scotland and Denmark
with acute undiagnosed abdominal pain, 106 patients later proved to have intraabdominal …

The present study retrospectively evaluates the clinical findings and survival rate following
treatment in 47 uterine torsion affected buffaloes. Uterine torsion was most frequently …

Platelets contribute to COVID-19 clinical manifestations, of which microclotting in the
pulmonary vasculature has been a prominent symptom. To investigate the potential diagnostic …

The tetrapeptide aldehyde Ac-Tyr-Val-Ala-AspH (1, L-709,049) has been reported to be a
potent reversible inhibitor of Interleukin-1β Converting Enzyme (ICE). We have prepared a …

The syntheses of cis- and trans-2-aminocyclopropyl, -cyclobutyl, -cyclopentyl, and -cyclohexylacetic
acids as γ-aminobutyric acid analogues of restricted conformation are described. …

Lyme disease is the most common tick-borne disease in Canada and the United States,
caused by Borrelia burgdorferi, which affects multiple organ systems. Epidemiology, clinical …