Chronic stress accelerates learning and memory impairments and increases amyloid deposition in APPV717I-CT100 transgenic mice, an Alzheimer's disease model

…, CH Park, J Yoo, KY Shin, SM Ahn, HS Kim, SH Lee… - 2006 - s-space.snu.ac.kr
Although chronic stress is known to be linked with memory and other neurological disorders,
little is known about the relationship between chronic stress and the onset or development …

Molecular interactions of antibody drugs targeting PD-1, PD-L1, and CTLA-4 in immuno-oncology

HT Lee, SH Lee, YS Heo - Molecules, 2019 - mdpi.com
Cancer cells can evade immune surveillance through the molecular interactions of immune
checkpoint proteins, including programmed death 1 (PD-1), PD-L1, and cytotoxic T …

Molecular mechanism of PD-1/PD-L1 blockade via anti-PD-L1 antibodies atezolizumab and durvalumab

HT Lee, JY Lee, H Lim, SH Lee, YJ Moon, HJ Pyo… - Scientific reports, 2017 - nature.com
In 2016 and 2017, monoclonal antibodies targeting PD-L1, including atezolizumab,
durvalumab, and avelumab, were approved by the FDA for the treatment of multiple advanced …

Activation of PERK signaling attenuates Aβ-mediated ER stress

DY Lee, KS Lee, HJ Lee, DH Kim, YH Noh, K Yu… - PloS one, 2010 - journals.plos.org
Alzheimer's disease (AD) is characterized by the deposition of aggregated beta-amyloid (Aβ),
which triggers a cellular stress response called the unfolded protein response (UPR). The …

[HTML][HTML] Analysis of complications following decompressive craniectomy for traumatic brain injury

…, YJ Son, HJ Yang, YS Chung, SH Lee… - Journal of Korean …, 2010 - ncbi.nlm.nih.gov
Objective Adequate management of increased intracranial pressure (ICP) is critical in patients
with traumatic brain injury (TBI), and decompressive craniectomy is widely used to treat …

Analysis of the factors influencing bone graft infection after cranioplasty

CH Lee, YS Chung, SH Lee, HJ Yang… - Journal of Trauma and …, 2012 - journals.lww.com
BACKGROUND Delayed cranioplasty after decompressive craniectomy was performed using
various reconstruction materials and methods. Bone graft infection is a major concern with …

Toxoplasma gondii Infection in the Brain Inhibits Neuronal Degeneration and Learning and Memory Impairments in a Murine Model of Alzheimer's Disease

…, YS Hwang, H Lim, SJ Lee, JH Moon, SH Lee… - PLoS …, 2012 - journals.plos.org
Immunosuppression is a characteristic feature of Toxoplasma gondii-infected murine hosts.
The present study aimed to determine the effect of the immunosuppression induced by T. …

Structural biology of the TNFα antagonists used in the treatment of rheumatoid arthritis

H Lim, SH Lee, HT Lee, JU Lee, JY Son… - International journal of …, 2018 - mdpi.com
The binding of the tumor necrosis factor α (TNFα) to its cognate receptor initiates many immune
and inflammatory processes. The drugs, etanercept (Enbrel ® ), infliximab (Remicade ® )…

Differences in pregnancy outcomes, prenatal care utilization, and maternal complications between teenagers and adult women in Korea: a nationwide …

SH Lee, SM Lee, NG Lim, HJ Kim, SH Bae, M Ock… - Medicine, 2016 - journals.lww.com
Teenage mothers are at high risk for maternal and neonatal complications. This study
aimed to evaluate the socioeconomic circumstances of teenage pregnancy, and determine …

Thromboembolic complications of elective coil embolization of unruptured aneurysms: the effect of oral antiplatelet preparation on periprocedural thromboembolic …

G Hwang, C Jung, SQ Park, HS Kang, SH Lee… - …, 2010 - journals.lww.com
OBJECTIVE: We retrospectively evaluated whether antiplatelet preparation lowered the
thromboembolic complication rate during the perioperative period. METHODS: We reviewed 328 …