User profiles for Shinobu Kawakatsu

Shinobu Kawakatsu

Fukushima Medical University
Verified email at fmu.ac.jp
Cited by 1486

[PDF][PDF] iPSC-based compound screening and in vitro trials identify a synergistic anti-amyloid β combination for Alzheimer's disease

…, M Nakagawa, T Asada, T Arai, S Kawakatsu… - Cell reports, 2017 - cell.com
In the process of drug development, in vitro studies do not always adequately predict human-specific
drug responsiveness in clinical trials. Here, we applied the advantage of human …

Typical and atypical appearance of early‐onset Alzheimer's disease: A clinical, neuroimaging and neuropathological study

S Kawakatsu, R Kobayashi, H Hayashi - Neuropathology, 2017 - Wiley Online Library
The International Working Group (IWG) has classified Alzheimer's disease (AD) as two different
types, the typical form and the atypical form, but clinicopathological studies of atypical AD …

[HTML][HTML] Non-pharmacological approaches to apathy and depression: a scoping review of mild cognitive impairment and dementia

H Oba, R Kobayashi, S Kawakatsu, K Suzuki… - Frontiers in …, 2022 - frontiersin.org
Apathy and depression are frequently observed as behavioral and psychological symptoms
of dementia, respectively, and are important for ensuring adequate care. This study aims to …

Paroxetine treatment of delusional disorder, somatic type

…, S Oshino, J Ishikawa, S Kawakatsu… - Human …, 2004 - Wiley Online Library
A 77‐year‐old female showed delusion of infestation in the oral cavity. She was treated by
paroxetine 20 mg/day, and the hypochondriacal delusion disappeared after 8 weeks. …

Morphology of the inner structure of the hippocampal formation in Alzheimer disease

M Adachi, S Kawakatsu, T Hosoya… - American journal …, 2003 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: To our knowledge, inner structural alterations of the
hippocampus have never been demonstrated because of the lack of contrast between the …

Effects of genetic defects in the CYP2C19 gene on the N‐demethylation of imipramine, and clinical outcome of imipramine therapy

…, T TANAKA, S KAWAKATSU… - Psychiatry and …, 1997 - Wiley Online Library
The relationship between the genetic polymorphism of S‐mephenytoin 4′‐hydroxylation
catalyzed by CYP2C19 and the N‐demethylation of imipramine was examined in 10 Japanese …

Steady-state plasma concentrations of imipramine and desipramine in relation to S-mephenytoin 4'-hydroxylation status in Japanese depressive patients

…, T Tanaka, K Chiba, S Kawakatsu… - Journal of clinical …, 1996 - journals.lww.com
The steady-state plasma concentrations of imipramine and desipramine were measured after
a more than 2-week treatment with 0.39 to 1.39 mg/kg/day of imipramine hydrochloride in …

[PDF][PDF] Assessment of demented patients by dynamic SPECT of inhaled xenon-133

…, M Kera, M Shinohara, S Kawakatsu - Journal of nuclear …, 1988 - Soc Nuclear Med
MATERIALS AND METhODS Patients All patients were in the early or early middle stage of
dementia. They underwent a detailed neuropsychologicalcx amination [DSM-3 (3), …

Repurposing bromocriptine for Aβ metabolism in Alzheimer's disease (REBRAnD) study: randomised placebo-controlled double-blind comparative trial and open …

…, K Shigenobu, Y Kutoku, Y Sunada, S Kawakatsu… - BMJ open, 2021 - bmjopen.bmj.com
Introduction Alzheimer’s disease (AD) is one of the most common causes of dementia.
Pathogenic variants in the presenilin 1 (PSEN1) gene are the most frequent cause of early-onset …

Clinicopathological heterogeneity of Alzheimer's disease with pure Alzheimer's disease pathology: Cases associated with dementia with Lewy bodies, very early …

S Kawakatsu, R Kobayashi, H Hayashi… - …, 2021 - Wiley Online Library
We report four cases depicting the heterogeneity of Alzheimer's disease (AD) associated
with pure AD pathology. Case 1 was a 77‐year‐old man with a false positive diagnosis of …