Intracellular calcium release is required for caspase‐3 and‐9 activation

L Tantral, K Malathi, S Kohyama… - Cell biochemistry …, 2004 - Wiley Online Library
Increase in intracellular Ca 2+ [Ca 2+ ]i regulates many biological functions including
apoptosis, but the protein(s) linking [Ca 2+ ]i and apoptosis are not completely understood. We …

The safety and efficacy of preoperative embolization of meningioma with N-butyl cyanoacrylate

…, Y Kakehi, N Uemiya, S Kohyama… - Interventional …, 2015 - journals.sagepub.com
Objective Preoperative embolization of meningioma is commonly performed; however,
there is no consensus on the best embolic material to reduce intraoperative blood loss and …

Optimal first coil selection to avoid aneurysmal recanalization in endovascular intracranial aneurysmal coiling

H Neki, S Kohyama, T Otsuka, A Yonezawa… - Journal of …, 2018 - jnis.bmj.com
Background Aneurysmal recanalization is a problem with endovascular coiling and one of
its risk factors is the low volume embolization ratio (VER). The first coil VER (1st VER) is …

Risk factors for coil protrusion into the parent artery and associated thrombo-embolic events following unruptured cerebral aneurysm embolization

…, Y Kakehi, N Uemiya, S Kohyama… - Interventional …, 2015 - journals.sagepub.com
Objective Advances in vascular reconstruction devices and coil technologies have made coil
embolization a popular and effective strategy for treatment of relatively wide-neck cerebral …

Inositol 1, 4, 5‐trisphosphate receptor (type 1) phosphorylation and modulation by Cdc2

K Malathi, S Kohyama, M Ho… - Journal of cellular …, 2003 - Wiley Online Library
Calcium (Ca 2+ ) release from the endoplasmic reticulum (ER) controls numerous cellular
functions including proliferation, and is regulated in part by inositol 1,4,5‐trisphosphate …

Altered expression of MicroRNA-15a and Kruppel-like factor 4 in cerebrospinal fluid and plasma after aneurysmal subarachnoid hemorrhage

…, H Nakajima, T Ikeda, R Takeda, H Neki, S Kohyama… - World Neurosurgery, 2017 - Elsevier
Background Cerebral vasospasm (CVS) is a major determinant of prognosis in patients with
subarachnoid hemorrhage (SAH). Alteration in the vascular phenotype contributes to …

Drip-and-ship thrombolytic therapy for acute ischemic stroke

I Deguchi, S Mizuno, S Kohyama, N Tanahashi… - Journal of Stroke and …, 2018 - Elsevier
Background Neuroendovascular therapy is a common treatment for patients with acute ischemic
stroke of the anterior circulation who fail to respond to recombinant tissue plasminogen …

Clinical features of neurogenic pulmonary edema in patients with subarachnoid hemorrhage

…, R Takeda, T Ikeda, Y Kikkawa, S Iihoshi, S Kohyama… - World Neurosurgery, 2020 - Elsevier
Objective Neurogenic pulmonary edema (NPE) is a clinical syndrome characterized by acute
onset after central nervous system injury. Here, we investigated the clinical features of NPE …

Risk factors and prevention of guiding catheter-induced vasospasm in neuroendovascular treatment

…, H Neki, Y Kakehi, N Uemiya, S Kohyama… - Neurologia medico …, 2015 - jstage.jst.go.jp
Mechanically-induced vasospasm often occurs during guiding catheter insertion, occasionally
preventing catheter advancement to the desired location. Delicate manipulation would be …

Clinical features of ruptured very small intracranial aneurysms (< 3 mm) in patients with subarachnoid hemorrhage

…, Y Take, A Teranishi, K Suzuki, S Kohyama… - World Neurosurgery, 2022 - Elsevier
Objective Although small unruptured aneurysms rarely rupture, many patients with subarachnoid
hemorrhage (SAH) have ruptured small, especially very small intracranial aneurysms (…