Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …

Risk stratification is critical for the early identification of high-risk individuals and disease
prevention. Here we explored the potential of nuclear magnetic resonance (NMR) spectroscopy-…

Background The use of levothyroxine to treat subclinical hypothyroidism is controversial. We
aimed to determine whether levothyroxine provided clinical benefits in older persons with …

Evidence is accumulating that aging is hormonally regulated by an evolutionarily conserved
insulin/IGF‐1 signalling (IIS) pathway. Mutations in IIS components affect lifespan in …

OBJECTIVES: To compare the risk of mortality of nonagenarian siblings with that of sporadic
nonagenarians (not selected on having a nonagenarian sibling) and to compare the …

The genetic contribution to the variation in human lifespan is ∼25%. Despite the large
number of identified disease-susceptibility loci, it is not known which loci influence population …

Background : High-sensitivity assays can quantify cardiac troponins I and T (hs-cTnI, hs-cTnT)
in individuals with no clinically manifest myocardial injury. Objectives : The goal of this …

Context: Subclinical thyroid dysfunction is common in older people. However, its clinical
importance is uncertain. Objective: Our objective was to determine the extent to which …

Predicting longer-term mortality risk requires collection of clinical data, which is often
cumbersome. Therefore, we use a well-standardized metabolomics platform to identify metabolic …

… Author links open overlay panel Diana van Heemst a , Simon P. Mooijaart a , Marian … a
41% increased survival (p=0.032) despite a 2.54 fold increased (p=0.007) proportional mortality …