This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, …

Migration of neurons from proliferative zones to their functional sites is fundamental to the
normal development of the central nervous system 1,2 . Mice homozygous for the spontaneous …

Cultured cells are dramatically affected by the micro‐environment in which they are grown.
In this study, we have investigated whether HepG2 liver cells grown in three dimensional (3‐D…

Background A-type lamins are type V intermediate filament proteins encoded by the gene
LMNA. Mutations in LMNA give rise to diverse degenerative diseases related to premature …

Methods with which to tailor the morphology of polystyrene-based emulsion-templated (PolyHIPE)
materials are presented. Increasing the temperature of the aqueous phase used to …

Migrating axons require the correct presentation of guidance molecules, often at multiple
choice points, to find their target. Netrin 1, a bifunctional cue involved in both attracting and …

Bone marrow-derived mesenchymal stem cells (MSCs) are attractive candidates for use in
regenerative medicine since they are easily accessible and can be readily expanded in vivo, …

Our current knowledge of how human tissues grow and develop is limited. We need to increase
our understanding of tissue formation if we are to fully realize the potential of stem cells …

Drug discovery programmes require accurate in vitro systems for drug screening and testing.
Traditional cell culture makes use of 2D (two-dimensional) surfaces for ex vivo cell growth. …

Emulsion templating has been used to prepare highly porous polyHIPE materials by thiol–ene
photoinitiated network formation. Commercially available multifunctional thiols and …