Automatic classification of MR scans in Alzheimer's disease
S Klöppel, CM Stonnington, C Chu, B Draganski… - Brain, 2008 - academic.oup.com
To be diagnostically useful, structural MRI must reliably distinguish Alzheimer's disease (AD)
from normal aging in individual scans. Recent advances in statistical learning theory have …
from normal aging in individual scans. Recent advances in statistical learning theory have …
Evidence for segregated and integrative connectivity patterns in the human basal ganglia
Detailed knowledge of the anatomy and connectivity pattern of cortico-basal ganglia circuits
is essential to an understanding of abnormal cortical function and pathophysiology …
is essential to an understanding of abnormal cortical function and pathophysiology …
Implementation of subjective cognitive decline criteria in research studies
Introduction Subjective cognitive decline (SCD) manifesting before clinical impairment
could serve as a target population for early intervention trials in Alzheimer's disease (AD). A …
could serve as a target population for early intervention trials in Alzheimer's disease (AD). A …
[PDF][PDF] Neue Entwicklungen in der Demenzdiagnostik
GW Eschweiler, T Leyhe, S Klöppel, M Hüll - Deutsches Ärzteblatt, 2010 - researchgate.net
Hintergrund: Demenz und Alzheimer-Krankheit werden oft synonym verwendet. Die Demenz
ist ein klinisches Syndrom mit dem Kernsymptom Gedächtnisstörung, das zu über 75 …
ist ein klinisches Syndrom mit dem Kernsymptom Gedächtnisstörung, das zu über 75 …
Estimating the age of healthy subjects from T1-weighted MRI scans using kernel methods: exploring the influence of various parameters
The early identification of brain anatomy deviating from the normal pattern of growth and
atrophy, such as in Alzheimer's disease (AD), has the potential to improve clinical outcomes …
atrophy, such as in Alzheimer's disease (AD), has the potential to improve clinical outcomes …
[HTML][HTML] BrainAGE in Mild Cognitive Impaired Patients: Predicting the Conversion to Alzheimer's Disease
Alzheimer’s disease (AD), the most common form of dementia, shares many aspects of
abnormal brain aging. We present a novel magnetic resonance imaging (MRI)-based biomarker …
abnormal brain aging. We present a novel magnetic resonance imaging (MRI)-based biomarker …
CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion
…, EY Kim, M Kimble, P King, ML Klimek, S Klöppel… - Neurology, 2012 - AAN Enterprises
Objective: Age at onset of diagnostic motor manifestations in Huntington disease (HD) is
strongly correlated with an expanded CAG trinucleotide repeat. The length of the normal CAG …
strongly correlated with an expanded CAG trinucleotide repeat. The length of the normal CAG …
Accuracy of dementia diagnosis—a direct comparison between radiologists and a computerized method
There has been recent interest in the application of machine learning techniques to
neuroimaging-based diagnosis. These methods promise fully automated, standard PC-based …
neuroimaging-based diagnosis. These methods promise fully automated, standard PC-based …
Consensus paper: combining transcranial stimulation with neuroimaging
…, L De Gennaro, AP Strafella, S Kähkönen, S Klöppel… - Brain stimulation, 2009 - Elsevier
In the last decade, combined transcranial magnetic stimulation (TMS)-neuroimaging studies
have greatly stimulated research in the field of TMS and neuroimaging. Here, we review …
have greatly stimulated research in the field of TMS and neuroimaging. Here, we review …
[HTML][HTML] Diagnostic neuroimaging across diseases
S Klöppel, A Abdulkadir, CR Jack Jr, N Koutsouleris… - Neuroimage, 2012 - Elsevier
Fully automated classification algorithms have been successfully applied to diagnose a wide
range of neurological and psychiatric diseases. They are sufficiently robust to handle data …
range of neurological and psychiatric diseases. They are sufficiently robust to handle data …