Automatic classification of MR scans in Alzheimer's disease

S Klöppel, CM Stonnington, C Chu, B Draganski… - Brain, 2008 - academic.oup.com
To be diagnostically useful, structural MRI must reliably distinguish Alzheimer's disease (AD)
from normal aging in individual scans. Recent advances in statistical learning theory have …

Evidence for segregated and integrative connectivity patterns in the human basal ganglia

B Draganski, F Kherif, S Klöppel, PA Cook… - Journal of …, 2008 - Soc Neuroscience
Detailed knowledge of the anatomy and connectivity pattern of cortico-basal ganglia circuits
is essential to an understanding of abnormal cortical function and pathophysiology …

Implementation of subjective cognitive decline criteria in research studies

…, KA Ellis, M Ewers, H Hampel, S Klöppel… - Alzheimer's & …, 2017 - Elsevier
Introduction Subjective cognitive decline (SCD) manifesting before clinical impairment
could serve as a target population for early intervention trials in Alzheimer's disease (AD). A …

[PDF][PDF] Neue Entwicklungen in der Demenzdiagnostik

GW Eschweiler, T Leyhe, S Klöppel, M Hüll - Deutsches Ärzteblatt, 2010 - researchgate.net
Hintergrund: Demenz und Alzheimer-Krankheit werden oft synonym verwendet. Die Demenz
ist ein klinisches Syndrom mit dem Kernsymptom Gedächtnisstörung, das zu über 75 …

Estimating the age of healthy subjects from T1-weighted MRI scans using kernel methods: exploring the influence of various parameters

K Franke, G Ziegler, S Klöppel, C Gaser… - Neuroimage, 2010 - Elsevier
The early identification of brain anatomy deviating from the normal pattern of growth and
atrophy, such as in Alzheimer's disease (AD), has the potential to improve clinical outcomes …

[HTML][HTML] BrainAGE in Mild Cognitive Impaired Patients: Predicting the Conversion to Alzheimer's Disease

C Gaser, K Franke, S Klöppel, N Koutsouleris, H Sauer… - PloS one, 2013 - journals.plos.org
Alzheimer’s disease (AD), the most common form of dementia, shares many aspects of
abnormal brain aging. We present a novel magnetic resonance imaging (MRI)-based biomarker …

CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion

…, EY Kim, M Kimble, P King, ML Klimek, S Klöppel… - Neurology, 2012 - AAN Enterprises
Objective: Age at onset of diagnostic motor manifestations in Huntington disease (HD) is
strongly correlated with an expanded CAG trinucleotide repeat. The length of the normal CAG …

Accuracy of dementia diagnosis—a direct comparison between radiologists and a computerized method

S Klöppel, CM Stonnington, J Barnes, F Chen, C Chu… - Brain, 2008 - academic.oup.com
There has been recent interest in the application of machine learning techniques to
neuroimaging-based diagnosis. These methods promise fully automated, standard PC-based …

Consensus paper: combining transcranial stimulation with neuroimaging

…, L De Gennaro, AP Strafella, S Kähkönen, S Klöppel… - Brain stimulation, 2009 - Elsevier
In the last decade, combined transcranial magnetic stimulation (TMS)-neuroimaging studies
have greatly stimulated research in the field of TMS and neuroimaging. Here, we review …

[HTML][HTML] Diagnostic neuroimaging across diseases

S Klöppel, A Abdulkadir, CR Jack Jr, N Koutsouleris… - Neuroimage, 2012 - Elsevier
Fully automated classification algorithms have been successfully applied to diagnose a wide
range of neurological and psychiatric diseases. They are sufficiently robust to handle data …