[HTML][HTML] HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors
…, SP Woods, AC Collier, CM Marra, S Morgello… - Journal of …, 2011 - Springer
Combination antiretroviral therapy (CART) has greatly reduced medical morbidity and
mortality with HIV infection, but high rates of HIV-associated neurocognitive disorders (HAND) …
mortality with HIV infection, but high rates of HIV-associated neurocognitive disorders (HAND) …
Validation of the CNS penetration-effectiveness rank for quantifying antiretroviral penetration into the central nervous system
…, JC McArthur, JA McCutchan, S Morgello… - Archives of …, 2008 - jamanetwork.com
Objective To evaluate whether penetration of a combination regimen into the central
nervous system (CNS), as estimated by the CNS Penetration-Effectiveness (CPE) rank, is …
nervous system (CNS), as estimated by the CNS Penetration-Effectiveness (CPE) rank, is …
Neurocognitive change in the era of HIV combination antiretroviral therapy: the longitudinal CHARTER study
…, BB Gelman, N Sacktor, S Morgello… - Clinical Infectious …, 2015 - academic.oup.com
Background. Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND)
can show variable clinical trajectories. Previous longitudinal studies of HAND typically …
can show variable clinical trajectories. Previous longitudinal studies of HAND typically …
[HTML][HTML] Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients
…, A Wurcel, T Zaman, D Stone, M Mefford, S Morgello… - PloS one, 2008 - journals.plos.org
Elevated plasma lipopolysaccharide (LPS), an indicator of microbial translocation from the
gut, is a likely cause of systemic immune activation in chronic HIV infection. LPS induces …
gut, is a likely cause of systemic immune activation in chronic HIV infection. LPS induces …
CD4 nadir is a predictor of HIV neurocognitive impairment in the era of combination antiretroviral therapy
…, AC Collier, B Gelman, J McArthur, S Morgello… - Aids, 2011 - journals.lww.com
Objective: Despite immune recovery in individuals on combination antiretroviral therapy (CART),
the frequency of HIV-associated neurocognitive disorders (HANDs) remains high. …
the frequency of HIV-associated neurocognitive disorders (HANDs) remains high. …
Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain
…, J Morgan, R Natividad, S Morgello… - Neuropathology and …, 2009 - Wiley Online Library
Aims: Microglia are involved in neurodegeneration, are prime targets for anti‐inflammatory
therapy and are potential biomarkers of disease progression. For example, positron emission …
therapy and are potential biomarkers of disease progression. For example, positron emission …
CNS invasion by CD14+/CD16+ peripheral blood-derived monocytes in HIV dementia: perivascular accumulation and reservoir of HIV infection
…, MW Richardson, S Amini, S Morgello… - Journal of …, 2001 - Springer
Increases in circulating CD14+/CD16+ monocytes have been associated with HIV dementia;
trafficking of these cells into the CNS has been proposed to play an important role in the …
trafficking of these cells into the CNS has been proposed to play an important role in the …
MR imaging of brain abscesses
…, RD Zimmerman, S Morgello… - American journal …, 1989 - Am Soc Neuroradiology
The MR images and CT scans of 14 patients with surgically verified pyogenic cerebral
abscesses were reviewed. The MR findings correlated well with those seen on CT and were …
abscesses were reviewed. The MR findings correlated well with those seen on CT and were …
Asymptomatic HIV-associated neurocognitive impairment increases risk for symptomatic decline
Objective: While HIV-associated neurocognitive disorders (HAND) remain prevalent despite
combination antiretroviral therapy (CART), the clinical relevance of asymptomatic …
combination antiretroviral therapy (CART), the clinical relevance of asymptomatic …
Continued high prevalence and adverse clinical impact of human immunodeficiency virus–associated sensory neuropathy in the era of combination antiretroviral …
…, JH Atkinson, RH Dworkin, S Morgello… - Archives of …, 2010 - jamanetwork.com
Objective To provide updated estimates of the prevalence and clinical impact of human
immunodeficiency virus−associated sensory neuropathy (HIV-SN) and neuropathic pain due to …
immunodeficiency virus−associated sensory neuropathy (HIV-SN) and neuropathic pain due to …