The extracellular matrix represents a complex alloy of variable members of diverse protein
families defining structural integrity and various physiological functions. The most abundant …

… In our studies (T Aigner, unpublished findings), we have confirmed that apoptosis occurs
in osteoarthritic cartilage, but at a very low rate with approximately 0.1% of the total cell …

Histological and histochemical methods are important tools in the evaluation of joint tissue
samples for degenerative joint diseases, both in humans and in animal models. In this respect…

Background: Current methods used to restore the joint surface in patients with localized
articular cartilage defects include transplantation of an autologous osteochondral cylinder and …

Objective Functional suitability and phenotypic stability of ectopic transplants are crucial factors
in the clinical application of mesenchymal stem cells (MSCs) for articular cartilage repair, …

Densely fossiliferous deposits are receiving increasing attention for their yield of paleobiologic
data and their usefulness in sedimentology and stratigraphy. This trend has created a …

Congenital nephrotic syndrome (CNS) is clinically and genetically heterogeneous, with
mutations in WT1, NPHS1 and NPHS2 accounting for part of cases. We recently delineated a …

… This nonparametric test is more likely to be appropriate than, for example, the t-test, because
it … Because of the limited number of cases to be compared in the in vitro investigations, the t-…

Objective Chondrocytes are crucial for adequate matrix balance and function. Cell proliferation
and, recently, extensive apoptotic cell death have been reported in osteoarthritic (OA) …

Connective tissues tend to heal naturally and successfully only if the injury is minor. If the
damage is more severe, then a good functional result can be achieved only if Nature is …