BACKGROUND: Structural brain abnormalities of the medial temporal lobe have been found
in people with bipolar disorder (BPD). It is not known whether these abnormalities progress …

Objectives: Strong qualitative and quantitative evidence exists of white matter abnormalities
in both schizophrenia and bipolar disorder (BD). Diffusion tensor imaging (DTI) studies …

BACKGROUND: Structural brain abnormalities in schizophrenia are well replicated; many
emerge before the onset of illness and are present in relatives who remain well. Structural …

BACKGROUND: Bipolar disorder is a familial psychiatric disorder associated with reduced
white matter integrity, but it is not clear whether such abnormalities are present in young …

Multicentre MRI studies offer great potential to increase study power and flexibility, but it is
not yet clear how reproducible the results from multiple centres may be. Here we present …

BACKGROUND: In our cohort considered at high risk (HR) of developing schizophrenia, we
previously found a significant difference in extent of right prefrontal cortical folding between …

BACKGROUND: There is growing evidence that the gene catechol-O-methyltransferase (COMT)
is involved in the etiopathogenesis of schizophrenia. This study sought to clarify the …

Background Schizophrenia is associated with cortical thickness reductions in the brain, but
it is unclear whether these are present before illness onset, and to what extent they are …

BACKGROUND: This study sought to assess white matter density in patients and relatives
with histories of bipolar disorder and/or schizophrenia. METHODS: Subjects included those …

Objectives: Abnormalities of ventral prefrontal function have been widely reported in bipolar
disorder, but reports of structural abnormalities in the same region are less consistent. We …