Current therapies for Parkinson's disease significantly improve the quality of life for patients
suffering from this neurodegenerative disease, yet none of the current therapies has been …

14-3-3s represent a family of highly conserved 30 kDa acidic proteins. 14-3-3s recognize
and bind specific phospho-sequences on client partners and operate as molecular hubs to …

Neurotrophin regulation of neuronal morphology is complex and may involve differential
action of alternative Trk receptor isoforms. We transfected ferret visual cortical slices with full-…

14-3-3 proteins are a family of proteins expressed throughout the body and implicated in many
diseases, from cancer to neurodegenerative disorders. While these proteins do not have …

… p < 0.05 compared to absence of exogenous CD by Student t-test. b. Double immunostaining
for CD and α-syn in the aggregation assay after transfection of H4 cells with α-syn+…

… using t-statistic followed by TDIST function (DF, t stat, 1) to calculate P. All quantification
was performed on a blinded basis. Specifically, each group was assigned an arbitrarily label, …

… 1 R μ i E t − i + ∑ j = 1 S ρ j Y t − j + v t where u t and ν t are white … t − l + v t We then augment
each of the two equations with m lags(5) E t = α + β 1 Y t − 1 + ⋯ + β l + m Y t − l − m + γ 1 E t …

… -EM image of exosomes purified from HEK-293 T cells expressing LRRK2 protein, scale
bar is 100 nm. (B) HEK-293 T cells expressing LRRK2 protein were co-transfected with eGFP, …

… Talene Yacoubian and David Standaert have a pending patent application regarding the
use of 14-3-3 proteins in the treatment of neurodegeneration. Sunny Slone, Adam Harrington, …

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common known cause of
inherited Parkinson's disease (PD), and LRRK2 is a risk factor for idiopathic PD. How LRRK2 …