Crohn's disease manifests during childhood or adolescence in up to 25% of patients. The
potential for linear growth impairment as a complication of chronic intestinal inflammation is …

Background Tumour necrosis factor ( TNF )‐antagonists have an established role in the
treatment of inflammatory bowel diseases ( IBDs ), however, subtherapeutic drug levels and the …

Background In the treatment of Crohn's disease ( CD ), mucosal healing has become a
major goal, with the hope of avoiding intestinal damage from chronic inflammation. Magnetic …

Background & Aims: Colonoscopic appearance, the primary measure of disease activity in
adult ulcerative colitis, is less acceptable to children. Our aim was to develop a noninvasive …

The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis are common
causes of morbidity in children and young adults in the western world. Here we report the …

Background Stricturing and penetrating complications account for substantial morbidity and
health-care costs in paediatric and adult onset Crohn's disease. Validated models to predict …

Interactions between the host and gut microbial community likely contribute to Crohn disease
(CD) pathogenesis; however, direct evidence for these interactions at the onset of disease …

Background Interleukin-10 (IL-10) signaling genes are attractive inflammatory bowel disease
(IBD) candidate genes as IL-10 restricts intestinal inflammation, IL-10 polymorphisms have …

… Conflicts of interest These authors disclose the following: Thomas Walters received research
support from Janssen and Abbvie. Anne Griffiths received research support and was a …

BACKGROUND & AIMS: In a prospective study of children with severe ulcerative colitis (UC),
we aimed to assess outcomes and to identify predictors of nonresponse to intravenous …