User profiles for T.M. Ryan

Tim Ryan

- Verified email at psu.edu - Cited by 5085

Timothy M. Ryan

- Verified email at unimelb.edu.au - Cited by 2735

The role of metallobiology and amyloid‐β peptides in Alzheimer's disease

BR Roberts, TM Ryan, AI Bush… - Journal of …, 2012 - Wiley Online Library
The role of metallobiology and amyloid╒β peptides in Alzheimer╎s disease Page 1
Introduction: metals in biology In eukaryotes, the most abundant biochemically functional metals …

Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease

…, TM Ryan, B Adler, TM Townes… - Proceedings of the …, 2001 - National Acad Sciences
Plasma xanthine oxidase (XO) activity was defined as a source of enhanced vascular
superoxide (O \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \…

Knockout-transgenic mouse model of sickle cell disease

TM Ryan, DJ Ciavatta, TM Townes - Science, 1997 - science.org
When transgenic mice that expressed human sickle hemoglobin were mated with mice
having knockout mutations of the mouse α- and β-globin genes, animals were produced that …

[HTML][HTML] Metalloproteomics: principles, challenges and applications to neurodegeneration

A Lothian, DJ Hare, R Grimm, TM Ryan… - Frontiers in aging …, 2013 - frontiersin.org
Trace elements are required for a variety of normal biological functions. As our understanding
of neurodegenerative disease advances we are identifying a number of metalloenzymes …

Correction of sickle cell disease by homologous recombination in embryonic stem cells

…, CW Sun, TM Ryan, KM Pawlik, J Ren, TM Townes - Blood, 2006 - ashpublications.org
Previous studies have demonstrated that sickle cell disease (SCD) can be corrected in
mouse models by transduction of hematopoietic stem cells with lentiviral vectors containing …

The primate semicircular canal system and locomotion

…, T Garland Jr, G Krovitz, TM Ryan… - Proceedings of the …, 2007 - National Acad Sciences
The semicircular canal system of vertebrates helps coordinate body movements, including
stabilization of gaze during locomotion. Quantitative phylogenetically informed analysis of the …

The semicircular canal system and locomotion: the case of extinct lemuroids and lorisoids

A Walker, TM Ryan, MT Silcox… - … : Issues, News, and …, 2008 - Wiley Online Library
Paleontologists reconstruct the locomotor and postural behavior of extinct species by analogy
with living forms and biomechanical analyses. In rare cases, behavioral evidence such as …

[HTML][HTML] Utility of an improved model of amyloid-beta (Aβ1-42) toxicity in Caenorhabditis elegansfor drug screening for Alzheimer's disease

…, VB Kenche, CM Roberts, CD Link, TM Ryan… - Molecular …, 2012 - Springer
Background The definitive indicator of Alzheimer’s disease (AD) pathology is the profuse
accumulation of amyloid-ß (Aß) within the brain. Various in vitro and cell-based models have …

Quantification and visualization of anisotropy in trabecular bone

RA Ketcham, TM Ryan - Journal of microscopy, 2004 - Wiley Online Library
A number of methods for measuring anisotropy in trabecular bone using high‐resolution X‐ray
computed tomography exist, which give different answers but have not been compared in …

Correction of a mouse model of sickle cell disease: lentiviral/antisickling β-globin gene transduction of unmobilized, purified hematopoietic stem cells

DN Levasseur, TM Ryan, KM Pawlik, TM Townes - Blood, 2003 - ashpublications.org
Although sickle cell anemia was the first hereditary disease to be understood at the
molecular level, there is still no adequate long-term treatment. Allogeneic bone marrow …