To discover susceptibility genes of late-onset Alzheimer’s disease (LOAD), we conducted a
3-stage genome-wide association study (GWAS) using three populations: Japanese from the …

Background and Purpose—Silent brain infarction (SBI) on MRI is common in elderly people,
and recent studies have demonstrated that SBI increases the risk of progression to clinically …

Aims Nationwide surveys to clarify the characteristics and trends of the drinking behavior of
Japanese adults were carried out in 2003, 2008, and 2013. Methods These were periodical …

The presence of cerebral white matter lesions (WMLs) on MRI is suggested to be a predictive
factor for vascular dementia and stroke. To investigate the relationship between arterial …

The aim of our study was to investigate the effects of silent brain lesions on cognitive function
of community-dwelling elderly individuals. Brain magnetic resonance imaging and other …

Rare non-synonymous variants of TREM2 have recently been shown to be associated with
Alzheimer’s disease (AD) in Caucasians. We here conducted a replication study using a well-…

We performed brain gradient-echo T2 ∗ -weighted magnetic resonance imaging (GE-MRI)
in community-dwelling healthy people to investigate the clinical correlates (ie, possible risk …

Patients with alcohol use disorder (AUD) have difficulty controlling their alcohol cravings
and thus exhibit increased use and early relapse. Although patients tend to respond more …

Neurodegeneration in bipolar disorder ( BPD ) is poorly understood. Therefore, the current
study was designed to assess the immunohistochemical changes in neurodegenerative …

Background Physical inactivity is one of the modifiable risk factors for hippocampal atrophy
and Alzheimer's disease. We investigated the relationship between physical activity, …