11C-l-Methionine Positron Emission Tomography in the Clinical Management of Cerebral Gliomas

T Singhal, TK Narayanan, V Jain, J Mukherjee… - Molecular imaging and …, 2008 - Springer
Positron emission tomography (PET) using l-[methyl- 11 C]-methionine (MET) is the most
popular amino acid imaging modality in oncology, although its use is restricted to PET centers …

Brain imaging of 18F‐fallypride in normal volunteers: Blood analysis, distribution, test‐retest studies, and preliminary assessment of sensitivity to aging effects on …

…, BT Christian, KA Dunigan, B Shi, TK Narayanan… - Synapse, 2002 - Wiley Online Library
Human studies of dopamine D2/D3 receptors using 18 F‐fallypride‐PET in normal volunteers
were performed to evaluate brain distribution in striatal and extrastriatal regions, evaluate …

Nicotinic α4β2 receptor imaging agents: part II. Synthesis and biological evaluation of 2-[18F] fluoro-3-[2-((S)-3-pyrrolinyl) methoxy] pyridine (18F-nifene) in rodents …

…, D Collins, BT Christian, B Shi, TK Narayanan… - Nuclear medicine and …, 2006 - Elsevier
The α4β2 nicotinic acetylcholine receptor (nAChR) has been implicated in various
neurodegenerative diseases. Optimal positron emission tomography (PET) imaging agents are …

11C-methionine PET for grading and prognostication in gliomas: a comparison study with 18F-FDG PET and contrast enhancement on MRI

T Singhal, TK Narayanan, MP Jacobs… - Journal of Nuclear …, 2012 - Soc Nuclear Med
The aim of this study was to compare the grading and prognostic value of l-[methyl- 11 C]-methionine
( 11 C-MET) PET in glioma patients with 18 F-FDG PET and contrast-enhanced MRI…

D2/D3 dopamine receptor binding with [F-18] fallypride in thalamus and cortex of patients with schizophrenia

…, BT Christian, DS Lehrer, TK Narayanan… - Schizophrenia …, 2006 - Elsevier
BACKGROUND: Abnormalities in the dopaminergic system are implicated in schizophrenia.
[F-18]fallypride is a highly selective, high affinity PET ligand well suited for measuring D2/D3 …

Synthesis and biologic evaluation of a novel serotonin 5-HT1A receptor radioligand, 18F-labeled mefway, in rodents and imaging by PET in a nonhuman primate

…, BT Christian, B Shi, TK Narayanan… - Journal of Nuclear …, 2006 - Soc Nuclear Med
Serotonin 5-HT 1A receptors have been implicated in disorders of the central nervous system
and, therefore, are being studied by PET. Efforts are under way to improve in vivo stability …

Measurement of d-amphetamine-induced effects on the binding of dopamine D-2/D-3 receptor radioligand, 18F-fallypride in extrastriatal brain regions in non-human …

J Mukherjee, BT Christian, TK Narayanan, B Shi… - Brain research, 2005 - Elsevier
The ability to measure amphetamine-induced dopamine release in extrastriatal brain
regions in the non-human primates was evaluated by using the dopamine D-2/D-3 receptor …

Measuring dopamine neuromodulation in the thalamus: using [F-18] fallypride PET to study dopamine release during a spatial attention task

BT Christian, DS Lehrer, B Shi, TK Narayanan… - Neuroimage, 2006 - Elsevier
We used the highly selective D2/D3 dopamine PET radioligand [F-18]fallypride to demonstrate
that cognitive task induced dopamine release can be measured in the extrastriatal region …

Interaction of gephyrotoxin and indolizidine alkaloids with the nicotinic acetylcholine receptorion channel complex of torpedo electroplax

…, JW Daly, TF Spande, TK Narayanan… - Neurochemical …, 1986 - Springer
The interactions of eighteen natural and synthetic gephyrotoxin and indolizidine alkaloids
with binding sites on nicotinic acetylcholine receptor channel (AChR) complex fromTorpedo …

Quantitation of striatal and extrastriatal D‐2 dopamine receptors using PET imaging of [18F]fallypride in nonhuman primates

BT Christian, TK Narayanan, B Shi, J Mukherjee - Synapse, 2000 - Wiley Online Library
[ 18 F]Fallypride is a highly selective, high‐affinity dopamine D‐2 receptor ligand. The high
affinity, K D = 30 pM, makes it a suitable candidate for visualizing both striatal and …