[HTML][HTML] Subgroup-specific structural variation across 1,000 medulloblastoma genomes

…, A Klekner, TE Van Meter, T Kumabe, T Tominaga… - Nature, 2012 - nature.com
Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated
with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive …

[HTML][HTML] A genome-wide association study identifies RNF213 as the first Moyamoya disease gene

…, Y Suzuki, A Hata, S Tsuchiya, T Tominaga… - Journal of human …, 2011 - nature.com
Moyamoya disease (MMD) shows progressive cerebral angiopathy characterized by bilateral
internal carotid artery stenosis and abnormal collateral vessels. Although∼ 15% of MMD …

Divergent clonal selection dominates medulloblastoma at recurrence

…, DW Fults, AW Walter, T Kumabe, T Tominaga… - Nature, 2016 - nature.com
The development of targeted anti-cancer therapies through the study of cancer genomes is
intended to increase survival rates and decrease treatment-related toxicity. We treated a …

Effects of extracranial–intracranial bypass for patients with hemorrhagic moyamoya disease: results of the Japan Adult Moyamoya Trial

…, N Hashimoto, Y Okada, I Tsuji, T Tominaga… - Stroke, 2014 - Am Heart Assoc
Background and Purpose— About one half of those who develop adult-onset moyamoya
disease experience intracranial hemorrhage. Despite the extremely high frequency of …

Mechanisms of primary blast-induced traumatic brain injury: insights from shock-wave research

…, H Yamamoto, K Takayama, T Tominaga - Journal of …, 2011 - liebertpub.com
Traumatic brain injury caused by explosive or blast events is traditionally divided into four
phases: primary, secondary, tertiary, and quaternary blast injury. These phases of blast-…

Cytogenetic prognostication within medulloblastoma subgroups

…, U Schüller, L Kren, T Kumabe, T Tominaga… - Journal of clinical …, 2014 - ascopubs.org
Purpose Medulloblastoma comprises four distinct molecular subgroups: WNT, SHH, Group 3,
and Group 4. Current medulloblastoma protocols stratify patients based on clinical features…

Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis

…, KKW Li, HK Ng, Y Yao, T Kumabe, T Tominaga… - The lancet …, 2016 - thelancet.com
Background Patients with incomplete surgical resection of medulloblastoma are controversially
regarded as having a marker of high-risk disease, which leads to patients undergoing …

The Tohoku medical megabank project: design and mission

…, S Ogishima, T Takai-Igarashi, T Tominaga… - Journal of …, 2016 - jstage.jst.go.jp
The Great East Japan Earthquake (GEJE) and resulting tsunami of March 11, 2011 gave
rise to devastating damage on the Pacific coast of the Tohoku region. The Tohoku Medical …

A proposed parent vessel geometry—based categorization of saccular intracranial aneurysms: computational flow dynamics analysis of the risk factors for lesion …

…, Y Matsumoto, K Takayama, T Tominaga… - Journal of …, 2005 - thejns.org
Object. The authors created a simple, broadly applicable classification of saccular
intracranial aneurysms into three categories: sidewall (SW), sidewall with branching vessel (SWBV), …

2021 Japanese guidelines for the management of Moyamoya disease: guidelines from the research committee on Moyamoya disease and Japan stroke society

M Fujimura, T Tominaga, S Kuroda… - Neurologia medico …, 2022 - jstage.jst.go.jp
… Cerebrovasc Dis 47: 178-187, 2019 36) Fujimura M, Inoue T, Shimizu H, Saito A, Mugikura
S, Tominaga T: Efficacy of prophylactic blood pressure lowering according to a standardized …