Emerging therapeutic opportunities for skeletal restoration

M Kawai, UI Mödder, S Khosla, CJ Rosen - Nature reviews Drug …, 2011 - nature.com
Osteoporosis, a syndrome characterized by thin bones and fractures, has become more
prevalent in both women and men. Established therapies for treating this disorder consist …

Concise review: Insights from normal bone remodeling and stem cell-based therapies for bone repair

S Khosla, JJ Westendorf, UI Mödder - Stem cells, 2010 - academic.oup.com
There is growing interest in the use of mesenchymal stem cells for bone repair. As a major
reason for normal bone remodeling is the removal of fatigue microcracks, advances in our …

Diffusion-and perfusion-weighted MRI: the DWI/PWI mismatch region in acute stroke

…, F Wenserski, M Siebler, RJ Seitz, U Mödder… - Stroke, 1999 - Am Heart Assoc
Background and Purpose—Diffusion-weighted imaging (DWI) and perfusion-weighted imaging
(PWI) are relatively new MR techniques increasingly used in acute stroke. During the first …

Radiation dose in dental radiology

…, J Kemper, O Möbes, J Pawelzik, U Mödder - European radiology, 2002 - Springer
The aim of this study was to compare radiation exposure in panoramic radiography (PR),
dental CT, and digital volume tomography (DVT). An anthropomorphic Alderson-Rando …

Relation of age, gender, and bone mass to circulating sclerostin levels in women and men

UI Mödder, KA Hoey, S Amin… - Journal of bone and …, 2011 - academic.oup.com
Sclerostin is a potent inhibitor of Wnt signaling and bone formation. However, there is currently
no information on the relation of circulating sclerostin levels to age, gender, or bone mass …

MRI-guided laser-induced interstitial thermotherapy of cerebral neoplasms

…, R Schober, G Fürst, U Mödder - Journal of computer …, 1994 - journals.lww.com
Objective Laser-induced interstitial thermotherapy (LITT) using a neodymium: yttrium aluminum
garnet (Nd: YAG) laser is a new therapeutic approach in the treatment of brain tumors. …

Effects of parathyroid hormone treatment on circulating sclerostin levels in postmenopausal women

MT Drake, B Srinivasan, UI Mödder… - The Journal of …, 2010 - academic.oup.com
Context: Intermittent PTH treatment stimulates bone formation, but the mechanism(s) of this
effect remain unclear. Sclerostin is an inhibitor of Wnt signaling, and animal studies have …

Regulation of circulating sclerostin levels by sex steroids in women and in men

UIL Mödder, JA Clowes, K Hoey… - Journal of Bone and …, 2011 - academic.oup.com
Sex steroids are important regulators of bone turnover, but the mechanisms of their effects
on bone remain unclear. Sclerostin is an inhibitor of Wnt signaling, and circulating estrogen (E…

Skeletal stem/osteoprogenitor cells: current concepts, alternate hypotheses, and relationship to the bone remodeling compartment

UI Mödder, S Khosla - Journal of cellular biochemistry, 2008 - Wiley Online Library
Plastic adherent bone marrow stromal cells have become synonymous with skeletal stem
cells, and perhaps rightfully so, as these cells have been extremely well characterized over the …

Radiation exposure of patients in comprehensive computed tomography of the head in acute stroke

…, LW Poll, A Saleh, U Mödder - American Journal …, 2006 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: To assess patient radiation exposure in comprehensive
stroke imaging using multidetector row CT (MDCT) combining standard CT of the head, …