Parkinson’s disease (PD) comprises a spectrum of disorders with differing subtypes, the
vast majority of which share Lewy bodies (LB) as a characteristic pathological hallmark. The …

… and Wüllner U. (2015) DNA methylation levels of asynuclein … and Wüllner U. (2010) Methylation
regulates alpha-synuclein … and Wüllner U. (2012) Genome-scale methylation analysis of …

Parkinson’s disease affects 5 million people worldwide, but the molecular mechanisms
underlying its pathogenesis are still unclear. Here, we report a genome-wide meta-analysis of …

… In addition to canonical genetics, epigenetic changes will have to be considered as well (Wüllner
et al. 2016). Several approaches are being explored in observational cohorts, …

Background Parkinson’s disease (PD) presently is conceptualized as a protein aggregation
disease in which pathology involves both the enteric and the central nervous system, …

There has been an unprecedented interest in the modulatory effects of intranasal oxytocin on
human social cognition and behaviour, however as yet no study has actually demonstrated …

Alpha-synuclein (SNCA) is a major risk gene for Parkinson's disease (PD), and increased
SNCA gene dosage results in a parkinsonian syndrome in affected families. We found that …

Machado–Joseph disease (MJD; also called spinocerebellar ataxia type 3) is a dominantly
inherited late-onset neurodegenerative disorder caused by expansion of polyglutamine (…

To study the putative association of dopamine agonists with sleep attacks in patients with
Parkinson's disease (PD) and their relation to daytime sleepiness, we performed a survey of …

To test whether the synucleinopathies Parkinson's disease and multiple system atrophy (MSA)
share a common genetic etiology, we performed a candidate single nucleotide …