Magnetic resonance imaging (MRI) has developed into the most important tool for the
diagnosis and monitoring of multiple sclerosis (MS). Its high sensitivity for the evaluation of …

The CD11c enhanced yellow fluorescent protein (EYFP) transgenic mouse was constructed
to identify dendritic cells in the periphery (Lindquist et al.[2004] Nat. Immunol. 5: 1243–1250)…

Chronic active multiple sclerosis lesions, characterized by a hyperintense rim of iron-enriched,
activated microglia and macrophages, have been linked to greater tissue damage. Post-…

The immune response to stroke is comprised of inflammatory and regulatory processes.
One cell type involved in both innate and adaptive immunity is the dendritic cell (DC). A DC …

A small proportion of multiple sclerosis (MS) patients develop new disease activity soon
after starting anti-CD20 therapy. This activity does not recur with further dosing, possibly …

Opinion statement Disease activity in multiple sclerosis (MS) has classically been defined
by the occurrence of new neurological symptoms and the rate of relapses. Definition of …

Dendritic cells (DC) are the professional antigen presenting cells (APC) that bridge the innate
and adaptive immune system. Previously, in a CD11c/EYFP transgenic mouse developed …

BACKGROUND AND PURPOSE: MR imaging studies have demonstrated that magnetic
susceptibility in multiple sclerosis lesions is dependent on lesion age. The objective of this …

Background Inflammation in chronic active lesions occurs behind a closed blood–brain barrier
and cannot be detected with MRI. Activated microglia are highly enriched for iron and can …

… Dr Kaunzner reported clinical study support from Genentech during the conduct of the study
and grants from Genentech and serving on advisory boards for Novartis and EMD Serono …