Extracellular vesicles (EVs), such as exosomes and microvesicles, are released by different
cell types and participate in physiological and pathophysiological processes. EVs mediate …

In the immature mammalian brain during a period of rapid growth (brain growth spurt/synaptogenesis
period), neuronal apoptosis can be triggered by the transient blockade of …

Substantial neurologic morbidity occurs in survivors of premature birth. Premature infants
are exposed to partial oxygen pressures that are fourfold higher compared to intrauterine …

Interleukin (IL)-18 is a potent inflammatory cytokine of the IL-1 family. It is synthesized as an
inactive precursor (pro-IL-18), which is cleaved into its functionally active form by caspase-1. …

Periventricular leukomalacia is the predominant injury in the preterm infant leading to cerebral
palsy. Oxygen exposure may be an additional cause of brain injury in these infants. In this …

Glutamate antagonists limit the growth of human cancers in vitro. The mechanism of
anticancer action of NMDA antagonists is not known, however. In this article, we report that the …

Neurotoxicity of anticancer agents complicates treatment of children with cancer. We
investigated neurotoxic effects of common cytotoxic drugs in neuronal cultures and in the …

Induced hypothermia is the only therapy with proven efficacy to reduce brain damage after
perinatal asphyxia. While hypothermia down-regulates global protein synthesis and cell …

Background: Untreated exposure to pain in preterm neonates might damage the vulnerable
premature brain and alter development. Pain treatment is limited because analgesic agents …

Infants born prematurely may develop neurocognitive deficits without an obvious cause.
Oxygen, which is widely used in neonatal medicine, constitutes one possible contributing …