Vocal fold wound healing: a review for clinicians

RC Branski, K Verdolini, V Sandulache, CA Rosen… - Journal of Voice, 2006 - Elsevier
The basic science of wound healing is largely omitted from the curriculum of many voice
clinicians. This fact is relatively disheartening as most therapeutic manipulation in the realm of …

Head and neck cancer survivorship consensus statement from the American Head and Neck Society

…, VA Patel, A Sacco, V Sandulache… - Laryngoscope …, 2022 - Wiley Online Library
Objectives To provide a consensus statement describing best practices and evidence
regarding head and neck cancer survivorship. Methods Key topics regarding head and neck …

The mouse Pax21Neu mutation is identical to a human PAX2 mutation in a family with renal-coloboma syndrome and results in developmental defects of the brain …

J Favor, R Sandulache… - Proceedings of the …, 1996 - National Acad Sciences
We describe a new mouse frameshift mutation (Pax2 1Neu ) with a 1-bp insertion in the Pax2
gene. This mutation is identical to a previously described mutation in a human family with …

TP53 Disruptive Mutations Lead to Head and Neck Cancer Treatment Failure through Inhibition of Radiation-Induced Senescence

HD Skinner, VC Sandulache, TJ Ow, RE Meyn… - Clinical cancer …, 2012 - AACR
Purpose: Mortality of patients with head and neck squamous cell carcinoma (HNSCC) is
primarily driven by tumor cell radioresistance leading to locoregional recurrence (LRR). In this …

Causes and consequences of adult laryngotracheal stenosis

A Gelbard, DO Francis, VC Sandulache… - The …, 2015 - Wiley Online Library
Objectives/Hypothesis Laryngotracheal stenosis (LTS) is largely considered a structural entity,
defined on anatomic terms (ie, percent stenosis, distance from vocal folds, overall length). …

Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation

…, D Sano, AA Patel, AM Ward, VC Sandulache… - Molecular cell, 2014 - cell.com
Many mutant p53 proteins (mutp53s) exert oncogenic gain-of-function (GOF) properties, but
the mechanisms mediating these functions remain poorly defined. We show here that GOF …

Persistent ethnicity-associated disparity in antitumor effectiveness of immune checkpoint inhibitors despite equal access

…, AC Chen, D Hernandez, VC Sandulache - Cancer research …, 2022 - AACR
We reviewed response to immune checkpoint inhibitors (ICI) of 207 patients with diagnoses
of lung or head and neck cancer treated with chemotherapy/ICI combination therapy and ICI …

Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells

VC Sandulache, TJ Ow, CR Pickering, MJ Frederick… - Cancer, 2011 - Wiley Online Library
BACKGROUND: Tumor metabolism is an essential contributor to disease progression and
response to treatment. An understanding of the metabolic phenotype of head and neck …

Prostaglandin E2 inhibition of keloid fibroblast migration, contraction, and transforming growth factor (TGF)‐β1–induced collagen synthesis

VC Sandulache, A Parekh… - Wound repair and …, 2007 - Wiley Online Library
Keloid formation has been linked to aberrant fibroblast activity, exacerbated by growth factors
and inflammatory mediators. Prostaglandin E2 (PGE2), synthesized from arachidonic acid …

Patterns of treatment failure in anaplastic thyroid carcinoma

…, GJ Cote, MD Williams, WN William, V Sandulache… - Thyroid, 2017 - liebertpub.com
Background: Anaplastic thyroid cancer (ATC) is one of the most lethal forms of cancer with a
high mortality rate. Current guidelines support surgery for resectable ATC followed by …