OBJECTIVE: Common estimates of the prevalence rate for pial arteriovenous malformations
(AVMs) of the brain vary widely, and their accuracy is questionable. Our objective was to …

Abnormal vascular remodeling mediated by inflammatory cells has been identified as a key
pathologic component of various vascular diseases, including abdominal aortic aneurysms, …

Background and Purpose— This review discusses recent research on the genetic,
molecular, cellular, and developmental mechanisms underlying the etiology of vascular …

… This paper is dedicated in memoriam to our colleague and friend William L Young, in
recognition of his contribution to brain arteriovenous malformations research and to the ARUBA trial…

… By using the unique skillsets gained from his training in anesthesia, Bill Young made major
… For all of these reasons and more, my colleagues and I remember Bill Young and the life he …

Background and Purpose— Evolution of intracranial aneurysmal disease is known to be related
to hemodynamic forces acting on the vessel wall. Low wall shear stress (WSS) has been …

… Cerebral arteriovenous malformations (AVM) are the underlying cause of a small proportion
of all strokes, but typically affect otherwise healthy young adults. The main goal of AVM …

… These membranes were mechanically durable with a Young's modulus of 12 MPa, which …
test system (Norwood, MA), and Young's modulus was obtained by quantifying the linear part …

… AVM hemorrhage and microsurgery can injure brain tissue, but young age and plasticity can
… All of these factors, hemorrhagic presentation, young age, compactness, and absence of …

Human pluripotent stem cells offer promise for use in cell-based therapies for brain injury
and diseases. However, their cellular behavior is poorly understood. Here we show that the …