Newborn screening (NBS) dramatically improves outcomes in severe childhood disorders
by treatment before symptom onset. In many genetic diseases, however, outcomes remain …

In this work we summarize our understanding of melanocortin 4 receptor (MC4R) pathway
activation, aiming to define a safe and effective therapeutic targeting strategy for the MC4R. …

Objective: To examine sex differences in the relationship between clinical symptoms related
to Alzheimer disease (AD) (verbal memory deficits) and neurodegeneration (hippocampal …

… The hippocampal W scores in autosomal dominant Alzheimer's disease were established
using age-matched controls, but were then compared against the W scores of the older stage …

Background Because studies of direct oral anticoagulants in patients with venous
thromboembolism and non-valvular atrial fibrillation have had minimal representation of morbidly …

Brain swelling is a major predictor of mortality in pediatric cerebral malaria (CM). However,
the mechanisms leading to swelling remain poorly defined. Here, we combined neuroimaging…

Animals prioritize behaviors according to their physiological needs and reproductive goals,
selecting a single behavioral strategy from a repertoire of possible responses to any given …

An important research application of amyloid imaging with positron emission tomography (PET)
is detection of the earliest evidence of fibrillar amyloid-beta (Aβ) deposition. Use of …

Background In animal studies, zinc supplementation inhibited phosphate-induced arterial
calcification. We tested the hypothesis that higher intake of dietary zinc was associated with …

The primary goal of this study was to assess the suitability of 11 C-Pittsburgh compound B (
11 C-PiB) blood–brain barrier delivery (K 1 ) and relative delivery (R 1 ) parameters as …