Judgement, as one of the core tenets of medicine, relies upon the integration of multilayered
data with nuanced decision making. Cancer offers a unique context for medical decisions …

Isocitrate dehydrogenase (IDH) mutant gliomas are the most common adult, malignant primary
brain tumors diagnosed in patients younger than 50, constituting an important cause of …

BACKGROUND AND PURPOSE: Stereotactic radiosurgery is known to control 85%–95% of
intracranial metastatic lesions during a median survival of 6–8 months. However, with the …

The early detection of relapse following primary surgery for non-small-cell lung cancer and
the characterization of emerging subclones, which seed metastatic sites, might offer new …

A high tumour mutational burden (hypermutation) is observed in some gliomas 1 , 2 , 3 , 4 –
5 ; however, the mechanisms by which hypermutation develops and whether it predicts the …

Background Brain metastases are associated with significant morbidity and mortality.
Population-level data describing the incidence and prognosis of patients with brain metastases are …

Purpose: Isocitrate dehydrogenase (IDH) mutations in glioma patients confer longer survival
and may guide treatment decision making. We aimed to predict the IDH status of gliomas …

Background Meningiomas are the most common primary intracranial tumor in adults.
Identification of SMO and AKT1 mutations in meningiomas has raised the possibility of targeted …

Melanoma brain metastasis (MBM) frequently occurs in patients with advanced melanoma;
yet, our understanding of the underlying salient biology is rudimentary. Here, we performed …

Background. High-grade gliomas with mutations in the isocitrate dehydrogenase (IDH) gene
family confer longer overall survival relative to their IDH-wild-type counterparts. Accurate …