In this Seminar, we highlight the main developments in the field of Alzheimer's disease. The
most recent data indicate that, by 2050, the prevalence of dementia will double in Europe …

Although the prevalence of dementia continues to increase worldwide, incidence in the
western world might have decreased as a result of better vascular care and improved brain …

… van der Flier n , Lidia Glodzik o , Argonde C. van Harten n , Mony J. de Leon o , Pauline
McHugh o , Michelle M. Mielke p , Jose Luis Molinuevo q , Lisa Mosconi o , Ricardo S. …

Importance Cerebral amyloid-β aggregation is an early pathological event in Alzheimer
disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid …

Alzheimer’s disease (AD) is highly heritable and recent studies have identified over 20
disease-associated genomic loci. Yet these only explain a small proportion of the genetic …

For many years, blood-based biomarkers for Alzheimer's disease seemed unattainable, but
recent results have shown that they could become a reality. Convincing data generated with …

Context Small single-center studies have shown that cerebrospinal fluid (CSF) biomarkers
may be useful to identify incipient Alzheimer disease (AD) in patients with mild cognitive …

A growing awareness about brain health and Alzheimer's disease in the general population
is leading to an increasing number of cognitively unimpaired individuals, who are …

A major unanswered question in the dementia field is whether cognitively unimpaired
individuals who harbor both Alzheimer’s disease neuropathological hallmarks (that is, amyloid-β …

… Lacunes are located in the white matter (WM) or subcortical grey matter and often have a
surrounding hyperintense halo. Microbleeds are small, round, hypointense foci on gradient …