… This paper is dedicated in memoriam to our colleague and friend William L Young, in
recognition of his contribution to brain arteriovenous malformations research and to the ARUBA trial…

… One of our associate editors, William L. Young, MD, passed away at the beginning of the
review process for this edition. The Remembrance section summarizes Bill’s enormous …

Background and Purpose— Evolution of intracranial aneurysmal disease is known to be related
to hemodynamic forces acting on the vessel wall. Low wall shear stress (WSS) has been …

Background A small proportion of strokes are caused by cerebral arteriovenous malformations
(AVM). Treatment to prevent intracranial haemorrhage itself carries risks, and untreated …

Nanostructured biomaterials have tremendous potential for tissue engineering. However,
the performance and integration of the nanomaterials in vivo are not well understood. A …

BACKGROUND Patient age, hemorrhagic presentation, nidal diffuseness, and deep
perforating artery supply are important factors when selecting patients with brain arteriovenous …

Human pluripotent stem cells offer promise for use in cell-based therapies for brain injury
and diseases. However, their cellular behavior is poorly understood. Here we show that the …

Objective Endothelial progenitor cells (EPCs) play an important role in tissue repairing and
regeneration in ischemic organs, including the brain. However, the cause of EPC migration …

Intracranial arteriovenous malformations (AVMs) are relatively uncommon but increasingly
recognized lesions that can cause serious neurological symptoms or death. Although AVMs …

Background and Purpose—Decisions on invasive arteriovenous malformation (AVM) treatment
are currently based on natural-course risk estimates of AVM bleeding and assumptions …