Results: In the active FM group, abdominal visceral and subcutaneous fat areas significantly
(P< 0.01) decreased from baseline by an average of 4.6%(mean (confidence interval):− 5.8 (…

Hypoxia has been proposed as an important microenvironmental factor in the development
of tissue fibrosis; however, the underlying mechanisms are not well defined. To examine the …

The kidney is a rich source of prostaglandins. These eicosanoids, formed by
cyclooxygenase-dependent metabolism of arachidonic acid, are important physiologic mediators of …

Chronic hypoxia accelerates renal fibrosis. The chief mediator of the hypoxic response is
hypoxia-inducible factor 1 (HIF-1) and its oxygen-sensitive component HIF-1α. HIF-1 regulates …

CTGF plays a significant role in the development of renal fibrosis by mediating the fibrotic
effects of transforming growth factor (TGF)-β 1 and has been shown to be hypoxia inducible in …

CIA (CCG1-interacting factor A)/ASF1, which is the most conserved histone chaperone among
the eukaryotes, was genetically identified as a factor for an anti-silencing function (Asf1) 1 …

We measured the plasma levels of adrenomedullin (AM), a novel vasodilating peptide, in 89
patients with various forms of systemic inflammatory response syndrome (SIRS) and 13 …

BACKGROUND: Depletion of glomerular podocytes is an important feature of progressive
diabetic nephropathy. Although the most plausible explanation for this podocyte depletion is …

Taking a new turn: An asymmetric Suzuki–Miyaura coupling of 1‐bromo‐2‐naphthalenephosphonic
esters with o‐methyl‐substituted phenylboronic acids proceeds with high …

Hypercalciuria is one of the early manifestations of diabetic nephropathy. We explored here
the role of α-Klotho, a protein expressed predominantly in distal convoluted tubules that has …