The role of individual factors in behavioural neuroscience is an important, but still neglected
area of research. The present review aims to give, first, an outline of the most elaborated …

Cellular senescence is characterized by stable cell-cycle arrest and a secretory program
that modulates the tissue microenvironment 1 , 2 . Physiologically, senescence serves as a …

It is currently thought that life-long blood cell production is driven by the action of a small
number of multipotent haematopoietic stem cells. Evidence supporting this view has been …

Immunotherapy has considerable potential in eliminating cancers by activating the host's
own immune system, while the thermal and mechanical effects of ultrasound have various …

Although great progress has been made in the characterization of the off-target effects of
engineered nucleases, sensitive and unbiased genome-wide methods for the detection of off-…

The extent to which the three-dimensional organization of the genome contributes to
chromosomal translocations is an important question in cancer genomics. We generated a high-…

Whereas chromosomal translocations are common pathogenetic events in cancer, mechanisms
that promote them are poorly understood. To elucidate translocation mechanisms in …

Although p53 inactivation promotes genomic instability 1 and presents a route to malignancy
for more than half of all human cancers 2 , 3 , the patterns through which heterogenous …

Chimeric antigen receptors (CARs) are synthetic receptors that target and reprogram T cells
to acquire augmented antitumor properties 1 . CD19-specific CARs that comprise CD28 and …

Arecoline is a naturally occurring psychoactive alkaloid from areca (betel) nuts of the areca
palm (Areca catechu) endemic to South and Southeast Asia. A partial agonist of nicotinic and …