Mammalian tooth crowns have precise functional requirements but cannot be substantially
remodeled after eruption. In developing teeth, epithelial signaling centers, the enamel knots, …

Clinical successes demonstrated by chimeric antigen receptor T-cell immunotherapy have
facilitated further development of T-cell immunotherapy against wide variety of diseases. One …

We have identified mouse and human cDNAs encoding a novel secreted BMP inhibitor, which
we have named ectodin. It is most homologous (∼37% amino acid identity) to sclerostin …

Objective To elucidate the pathologic role of follicular helper T (Tfh) cells and their subsets
in active, untreated IgG4‐related disease. Methods Fifteen patients with active, untreated, …

A non‐contrast‐enhanced three‐dimensional (3D) magnetic resonance angiography (MRA)
technique, which acquires images in a reasonably short scanning time and requires no …

Background The aim of this study was to elucidate the function of circulating follicular helper
T (Tfh) cell subsets in helping B cells in patients with active, untreated IgG4-related disease (…

… omics measurement, Y is an outcome vector of length n, T is an n × l matrix of orthogonal
scores, P is an m × l matrix of loading, B is a loading vector of length l, ε X and ε Y are the error …

Limited T cell availability and proliferative exhaustion present major barriers to successful T
cell-based immunotherapies and may potentially be overcome through the use of "…

Adoptive T-cell immunotherapy is a promising approach to cancer therapy. Stem cell memory
T (T SCM ) cells have been proposed as a class of long-lived and highly proliferative …

Objectives Multiomics study was conducted to elucidate the crucial molecular mechanisms of
primary Sjögren’s syndrome (SS) pathology. Methods We generated multiple data set from …