α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

YC Wong, D Krainc - Nature medicine, 2017 - nature.com
Alterations in α-synuclein dosage lead to familial Parkinson's disease (PD), and its accumulation
results in synucleinopathies that include PD, dementia with Lewy bodies (DLB) and …

Synaptic, mitochondrial, and lysosomal dysfunction in Parkinson's disease

M Nguyen, YC Wong, D Ysselstein, A Severino… - Trends in …, 2019 - cell.com
The discovery of genetic forms of Parkinson's disease (PD) has highlighted the importance
of the autophagy/lysosomal and mitochondrial/oxidative stress pathways in disease …

Regulation and function of mitochondria–lysosome membrane contact sites in cellular homeostasis

YC Wong, S Kim, W Peng, D Krainc - Trends in cell biology, 2019 - cell.com
Mitochondrial and lysosomal function are intricately related and critical for maintaining cellular
homeostasis, as highlighted by multiple diseases linked to dysfunction of both organelles. …

Adsorption of acid dyes on chitosan—equilibrium isotherm analyses

YC Wong, YS Szeto, WH Cheung, G McKay - Process biochemistry, 2004 - Elsevier
The ability of chitosan, derived from deacetylated crab shell chitin, to remove acid dyes from
effluent solution by adsorption has been studied. Equilibrium isotherms for the adsorption of …

[PDF][PDF] Acute SARS-CoV-2 infection impairs dendritic cell and T cell responses

R Zhou, KKW To, YC Wong, L Liu, B Zhou, X Li… - Immunity, 2020 - cell.com
The SARS-CoV-2 pandemic has resulted in millions of infections, yet the role of host immune
responses in early COVID-19 pathogenesis remains unclear. By investigating 17 acute and …

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

YC Wong, ELF Holzbaur - Proceedings of the National …, 2014 - National Acad Sciences
Mitophagy is a cellular quality control pathway in which the E3 ubiquitin ligase parkin targets
damaged mitochondria for degradation by autophagosomes. We examined the role of …

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease

…, P Song, JR Mazzulli, E Zampese, YC Wong… - Science, 2017 - science.org
Mitochondrial and lysosomal dysfunction have been implicated in substantia nigra dopaminergic
neurodegeneration in Parkinson’s disease (PD), but how these pathways are linked in …

Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis

YC Wong, D Ysselstein, D Krainc - Nature, 2018 - nature.com
Both mitochondria and lysosomes are essential for maintaining cellular homeostasis, and
dysfunction of both organelles has been observed in multiple diseases 1 , 2 , 3 , 4 . …

Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target

…, CW Chua, KW Chan, FL Chan, C Glackin, YC Wong… - Cancer research, 2005 - AACR
Androgen-independent metastatic prostate cancer is the main obstacle in the treatment of this
cancer. Unlike a majority of solid cancers, prostate cancer usually shows poor response to …

Equilibrium studies for acid dye adsorption onto chitosan

YC Wong, YS Szeto, WH Cheung, G McKay - Langmuir, 2003 - ACS Publications
The ability of chitosan as an adsorbent for the removal of acid dyestuff, namely, acid green
25, acid orange 10, acid orange 12, acid red 18, and acid red 73, from aqueous solution has …