User profiles for Y.I. Chen

Yi Chen

- Verified email at seu.edu.cn - Cited by 3806

Yi-Ling Chen

- Verified email at microsoft.com - Cited by 1430

A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

…, Z Chen, Y Guo, J Zhang, Y Li, X Song, Y Chen… - Science, 2020 - science.org
Developing therapeutics against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
could be guided by the distribution of epitopes, not only on the receptor binding …

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

DJ Cua, J Sherlock, YI Chen, CA Murphy, B Joyce… - Nature, 2003 - nature.com
Interleukin-12 (IL-12) is a heterodimeric molecule composed of p35 and p40 subunits.
Analyses in vitro have defined IL-12 as an important factor for the differentiation of naive T cells …

KCNQ1 gain-of-function mutation in familial atrial fibrillation

YH Chen, SJ Xu, S Bendahhou, XL Wang, Y Wang… - Science, 2003 - science.org
Atrial fibrillation (AF) is a common cardiac arrhythmia whose molecular etiology is poorly
understood. We studied a family with hereditary persistent AF and identified the causative …

[HTML][HTML] Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

…, P Sopp, D Wellington, U Rajapaksa, YL Chen… - Nature …, 2020 - nature.com
The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines
and therapeutics will depend on understanding viral immunity. We studied T cell memory …

[HTML][HTML] A wearable and highly sensitive pressure sensor with ultrathin gold nanowires

S Gong, W Schwalb, Y Wang, Y Chen, Y Tang… - Nature …, 2014 - nature.com
Ultrathin gold nanowires are mechanically flexible yet robust, which are novel building blocks
with potential applications in future wearable optoelectronic devices. Here we report an …

[HTML][HTML] Genome sequencing in microfabricated high-density picolitre reactors

…, J Berka, MS Braverman, YJ Chen, Z Chen… - Nature, 2005 - nature.com
The proliferation of large-scale DNA-sequencing projects in recent years has driven a
search for alternative methods to reduce time and cost. Here we describe a scalable, highly …

Scaling up visual and vision-language representation learning with noisy text supervision

C Jia, Y Yang, Y Xia, YT Chen… - International …, 2021 - proceedings.mlr.press
Pre-trained representations are becoming crucial for many NLP and perception tasks. While
representation learning in NLP has transitioned to training on raw text without human …

Development and cross–cultural application of a specific instrument to measure entrepreneurial intentions

F Liñán, YW Chen - Entrepreneurship theory and practice, 2009 - journals.sagepub.com
This article uses Ajzen's theory of planned behavior to build an entrepreneurial intention
questionnaire (EIQ) and analyzes its psychometric properties. The entrepreneurial intention …

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

CL Langrish, Y Chen, WM Blumenschein… - The Journal of …, 2005 - rupress.org
Interleukin (IL)-23 is a heterodimeric cytokine composed of a unique p19 subunit, and a
common p40 subunit shared with IL-12. IL-12 is important for the development of T helper (Th)1 …

[HTML][HTML] The complete genome of an individual by massively parallel DNA sequencing

…, Y Shen, L Chen, A McGuire, W He, YJ Chen… - nature, 2008 - nature.com
The association of genetic variation with disease and drug response, and improvements in
nucleic acid technologies, have given great optimism for the impact of ‘genomic medicine’. …