A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2
…, Z Chen, Y Guo, J Zhang, Y Li, X Song, Y Chen… - Science, 2020 - science.org
Developing therapeutics against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
could be guided by the distribution of epitopes, not only on the receptor binding …
could be guided by the distribution of epitopes, not only on the receptor binding …
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
Interleukin-12 (IL-12) is a heterodimeric molecule composed of p35 and p40 subunits.
Analyses in vitro have defined IL-12 as an important factor for the differentiation of naive T cells …
Analyses in vitro have defined IL-12 as an important factor for the differentiation of naive T cells …
KCNQ1 gain-of-function mutation in familial atrial fibrillation
YH Chen, SJ Xu, S Bendahhou, XL Wang, Y Wang… - Science, 2003 - science.org
Atrial fibrillation (AF) is a common cardiac arrhythmia whose molecular etiology is poorly
understood. We studied a family with hereditary persistent AF and identified the causative …
understood. We studied a family with hereditary persistent AF and identified the causative …
[HTML][HTML] Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19
…, P Sopp, D Wellington, U Rajapaksa, YL Chen… - Nature …, 2020 - nature.com
The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines
and therapeutics will depend on understanding viral immunity. We studied T cell memory …
and therapeutics will depend on understanding viral immunity. We studied T cell memory …
[HTML][HTML] A wearable and highly sensitive pressure sensor with ultrathin gold nanowires
Ultrathin gold nanowires are mechanically flexible yet robust, which are novel building blocks
with potential applications in future wearable optoelectronic devices. Here we report an …
with potential applications in future wearable optoelectronic devices. Here we report an …
[HTML][HTML] Genome sequencing in microfabricated high-density picolitre reactors
…, J Berka, MS Braverman, YJ Chen, Z Chen… - Nature, 2005 - nature.com
The proliferation of large-scale DNA-sequencing projects in recent years has driven a
search for alternative methods to reduce time and cost. Here we describe a scalable, highly …
search for alternative methods to reduce time and cost. Here we describe a scalable, highly …
Scaling up visual and vision-language representation learning with noisy text supervision
Pre-trained representations are becoming crucial for many NLP and perception tasks. While
representation learning in NLP has transitioned to training on raw text without human …
representation learning in NLP has transitioned to training on raw text without human …
Development and cross–cultural application of a specific instrument to measure entrepreneurial intentions
F Liñán, YW Chen - Entrepreneurship theory and practice, 2009 - journals.sagepub.com
This article uses Ajzen's theory of planned behavior to build an entrepreneurial intention
questionnaire (EIQ) and analyzes its psychometric properties. The entrepreneurial intention …
questionnaire (EIQ) and analyzes its psychometric properties. The entrepreneurial intention …
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
CL Langrish, Y Chen, WM Blumenschein… - The Journal of …, 2005 - rupress.org
Interleukin (IL)-23 is a heterodimeric cytokine composed of a unique p19 subunit, and a
common p40 subunit shared with IL-12. IL-12 is important for the development of T helper (Th)1 …
common p40 subunit shared with IL-12. IL-12 is important for the development of T helper (Th)1 …
[HTML][HTML] The complete genome of an individual by massively parallel DNA sequencing
…, Y Shen, L Chen, A McGuire, W He, YJ Chen… - nature, 2008 - nature.com
The association of genetic variation with disease and drug response, and improvements in
nucleic acid technologies, have given great optimism for the impact of ‘genomic medicine’. …
nucleic acid technologies, have given great optimism for the impact of ‘genomic medicine’. …