Medulloblastomics: the end of the beginning
The division of medulloblastoma into different subgroups by microarray expression profiling
has dramatically changed our perspective of this malignant childhood brain tumour. Now, …
has dramatically changed our perspective of this malignant childhood brain tumour. Now, …
Pediatric high-grade glioma: biologically and clinically in need of new thinking
High-grade gliomas in children are different from those that arise in adults. Recent collaborative
molecular analyses of these rare cancers have revealed previously unappreciated …
molecular analyses of these rare cancers have revealed previously unappreciated …
The efficacy and safety of prone positional ventilation in acute respiratory distress syndrome: updated study-level meta-analysis of 11 randomized controlled trials
Objective: The survival benefit of prone positioning during mechanical ventilation for acute
respiratory distress syndrome has been a matter of debate. Recent multicenter randomized …
respiratory distress syndrome has been a matter of debate. Recent multicenter randomized …
Introducing EzTaxon-e: a prokaryotic 16S rRNA gene sequence database with phylotypes that represent uncultured species
Despite recent advances in commercially optimized identification systems, bacterial identification
remains a challenging task in many routine microbiological laboratories, especially in …
remains a challenging task in many routine microbiological laboratories, especially in …
The landscape of somatic copy-number alteration across human cancers
A powerful way to discover key genes with causal roles in oncogenesis is to identify
genomic regions that undergo frequent alteration in human cancers. Here we present high-…
genomic regions that undergo frequent alteration in human cancers. Here we present high-…
[HTML][HTML] Molecular subgroups of medulloblastoma: the current consensus
Medulloblastoma, a small blue cell malignancy of the cerebellum, is a major cause of morbidity
and mortality in pediatric oncology. Current mechanisms for clinical prognostication and …
and mortality in pediatric oncology. Current mechanisms for clinical prognostication and …
[HTML][HTML] Dissecting the genomic complexity underlying medulloblastoma
Medulloblastoma is an aggressively growing tumour, arising in the cerebellum or medulla/brain
stem. It is the most common malignant brain tumour in children, and shows tremendous …
stem. It is the most common malignant brain tumour in children, and shows tremendous …
[HTML][HTML] Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences
Tumour cells release an abundance of microvesicles containing a selected set of proteins
and RNAs. Here, we show that tumour microvesicles also carry DNA, which reflects the …
and RNAs. Here, we show that tumour microvesicles also carry DNA, which reflects the …
[HTML][HTML] Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and …
Medulloblastoma is the most common malignant brain tumor in childhood. Molecular studies
from several groups around the world demonstrated that medulloblastoma is not one …
from several groups around the world demonstrated that medulloblastoma is not one …
[HTML][HTML] Subgroup-specific structural variation across 1,000 medulloblastoma genomes
Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated
with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive …
with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive …