Dysmyelinating diseases, or leukodystrophies, encompass a wide spectrum of inherited
neurodegenerative disorders affecting the integrity of myelin in the brain and peripheral …

Chapter 57 ularly shaped, elongated or round hyaline eosinophilic bodies up to 50mm in
length with a diameter of 1–25mm. They are arranged radially around blood vessels and …

Now more streamlined and focused than ever before, the 6th edition of CT and MRI of the
Whole Body is a definitive reference that provides you with an enhanced understanding of …

Alexander disease is a very rare congenital and untreatable white matter disease. It affects
the astroglia of the central nervous system exclusively and is characterized histologically by …

We describe a progressive neurologic disorder in three sisters characterized clinically by
palatal myoclonus, spastic weakness, hyperreflexia, mild cerebellar dysfunction, and ocular …

White matter diseases can be broadly separated into 3 main categories: diseases that affect
myelin metabolism, diseases that result in direct damage to myelin and/or oligodendrocytes …

Cerebral magnetic resonance imaging and spectroscopy form an integral part in the
diagnosis and management of the vast spectrum of metabolic and degenerative disorders in …

A 17-year-old male was diagnosed as having Alexander disease from the clinical
manifestations (psychomotor deterioration and megalencephaly), neuroradiologic findings …

We describe two unrelated girls with slowly progressive leukodystrophy with macrocephaly.
On MRI, both patients exhibited diffuse involvement of the cerebral white matter, excluding …

Metabolic disorders of the brain are rare, complex and confusing. The diagnostic modality of
choice nowadays is MRI. The high diagnostic sensitivity, however, is coupled with a lack of …