The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: two sides of the same coin
DG Peters, JR Connor, MD Meadowcroft - Neurobiology of disease, 2015 - Elsevier
The dysregulation of iron metabolism in Alzheimer's disease is not accounted for in the
current framework of the amyloid cascade hypothesis. Accumulating evidence suggests that …
current framework of the amyloid cascade hypothesis. Accumulating evidence suggests that …
Cardiovascular disease in Down syndrome
P Versacci, D Di Carlo, MC Digilio… - Current opinion in …, 2018 - journals.lww.com
Cardiovascular disease in Down syndrome : Current Opinion in Pediatrics Cardiovascular
disease in Down syndrome : Current Opinion in Pediatrics Log in or Register Subscribe to …
disease in Down syndrome : Current Opinion in Pediatrics Log in or Register Subscribe to …
The four ages of Down syndrome
Background: Down syndrome (DS) affects∼ 1 per 650–1000 live births and is the most
common known genetic cause of intellectual disability. A highly significant change in the …
common known genetic cause of intellectual disability. A highly significant change in the …
Multimorbidity in older adults with intellectual disabilities
H Hermans, HM Evenhuis - Research in Developmental Disabilities, 2014 - Elsevier
Multimorbidity may be related to the supposed early aging of people with intellectual
disabilities (ID). This group may suffer more often from multimorbidity, because of ID-related …
disabilities (ID). This group may suffer more often from multimorbidity, because of ID-related …
[HTML][HTML] Brain-predicted age in Down syndrome is associated with beta amyloid deposition and cognitive decline
Individuals with Down syndrome (DS) are more likely to experience earlier onset of multiple
facets of physiological aging. This includes brain atrophy, beta amyloid deposition, cognitive …
facets of physiological aging. This includes brain atrophy, beta amyloid deposition, cognitive …
Down syndrome: a cardiovascular perspective
JC Vis, MGJ Duffels, MM Winter… - Journal of …, 2009 - Wiley Online Library
This review focuses on the heart and vascular system in patients with Down syndrome. A
clear knowledge on the wide spectrum of various abnormalities associated with this …
clear knowledge on the wide spectrum of various abnormalities associated with this …
Usp16 contributes to somatic stem-cell defects in Down's syndrome
Down's syndrome results from full or partial trisomy of chromosome 21. However, the
consequences of the underlying gene–dosage imbalance on adult tissues remain poorly …
consequences of the underlying gene–dosage imbalance on adult tissues remain poorly …
The triple challenges associated with age‐related comorbidities in D own syndrome
EJ Glasson, DE Dye, AH Bittles - Journal of Intellectual …, 2014 - Wiley Online Library
Background Major increases in the survival of people with D own syndrome during the last
two generations have resulted in extended periods of adulthood requiring specialist care …
two generations have resulted in extended periods of adulthood requiring specialist care …
Bone mineral density and muscle strength in young men with mental retardation (with and without Down syndrome)
N Angelopoulou, C Matziari, V Tsimaras… - Calcified Tissue …, 2000 - Springer
The objective of this study was to compare the bone mineral density (BMD) of men with
Down syndrome (DS) to otherwise mentally retarded (MR) men and to investigate whether …
Down syndrome (DS) to otherwise mentally retarded (MR) men and to investigate whether …
Brain volume preserved in healthy elderly through the eleventh decade
EA Mueller, MM Moore, DCR Kerr, G Sexton… - Neurology, 1998 - AAN Enterprises
Objective: To determine which brain regions lose volume with aging over time in healthy,
nondemented elderly. Background: Cross-sectional studies suggest widespread loss of …
nondemented elderly. Background: Cross-sectional studies suggest widespread loss of …