Brain atrophy in Alzheimer's disease and aging

L Pini, M Pievani, M Bocchetta, D Altomare… - Ageing research …, 2016 - Elsevier
Thanks to its safety and accessibility, magnetic resonance imaging (MRI) is extensively used
in clinical routine and research field, largely contributing to our understanding of the …

[HTML][HTML] Diagnostic biomarkers of Alzheimer's disease: a state-of-the-art review

R Khoury, E Ghossoub - Biomarkers in Neuropsychiatry, 2019 - Elsevier
In 2018, there was a recent shift towards a biological definition of Alzheimer's disease (AD),
based on biomarkers measured in vivo even before the onset of clinical dementia …

Mapping the evolution of regional atrophy in Alzheimer's disease: unbiased analysis of fluid-registered serial MRI

RI Scahill, JM Schott, JM Stevens… - Proceedings of the …, 2002 - National Acad Sciences
Alzheimer's disease (AD) is characterized by progressive cerebral atrophy, which may be
assessed by using volumetric MRI. We describe a voxel-based analysis of nonlinear …

Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease

AT Du, N Schuff, D Amend, MP Laakso… - Journal of Neurology …, 2001 - jnnp.bmj.com
OBJECTIVES To explore volume changes of the entorhinal cortex (ERC) and hippocampus
in mild cognitive impairment (MCI) and Alzheimer's disease (AD) compared with normal …

Hippocampus and entorhinal cortex in mild cognitive impairment and early AD

C Pennanen, M Kivipelto, S Tuomainen… - Neurobiology of …, 2004 - Elsevier
Magnetic resonance imaging (MRI) has been suggested as a useful tool in early diagnosis
of Alzheimer's disease (AD). Based on MRI-derived volumes, we studied the hippocampus …

Patterns of temporal lobe atrophy in semantic dementia and Alzheimer's disease

D Chan, NC Fox, RI Scahill, WR Crum… - Annals of …, 2001 - Wiley Online Library
Volumetric magnetic resonance imaging analyses of 30 subjects were undertaken to
quantify the global and temporal lobe atrophy in semantic dementia and Alzheimer's …

[HTML][HTML] A large-scale comparison of cortical thickness and volume methods for measuring Alzheimer's disease severity

CG Schwarz, JL Gunter, HJ Wiste, SA Przybelski… - NeuroImage: Clinical, 2016 - Elsevier
Alzheimer's disease (AD) researchers commonly use MRI as a quantitative measure of
disease severity. Historically, hippocampal volume has been favored. Recently,“AD …

Multidimensional classification of hippocampal shape features discriminates Alzheimer's disease and mild cognitive impairment from normal aging

E Gerardin, G Chételat, M Chupin, R Cuingnet… - Neuroimage, 2009 - Elsevier
We describe a new method to automatically discriminate between patients with Alzheimer's
disease (AD) or mild cognitive impairment (MCI) and elderly controls, based on …

MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer's disease

BC Dickerson, I Goncharova, MP Sullivan… - Neurobiology of …, 2001 - Elsevier
With high resolution, quantitative magnetic resonance imaging (MRI) techniques, it is now
possible to examine alterations in brain anatomy in vivo and to identify regions affected in …

Early diagnosis of Alzheimer׳ s disease based on partial least squares, principal component analysis and support vector machine using segmented MRI images

L Khedher, J Ramírez, JM Górriz, A Brahim, F Segovia… - Neurocomputing, 2015 - Elsevier
Computer aided diagnosis (CAD) systems using functional and structural imaging
techniques enable physicians to detect early stages of the Alzheimer׳ s disease (AD). For …