Adequate supply of blood and structural and functional integrity of blood vessels are key to
normal brain functioning. On the other hand, cerebral blood flow shortfalls and blood–brain …

The global prevalence of dementia is estimated to be as high as 24 million, and is predicted
to double every 20 years through to 2040, leading to a costly burden of disease. Alzheimer …

Imaging has played a variety of roles in the study of Alzheimer disease (AD) over the past
four decades. Initially, computed tomography (CT) and then magnetic resonance imaging …

Increasing evidence from epidemiological, clinical and experimental studies indicate that
age-related cerebromicrovascular dysfunction and microcirculatory damage play critical …

Functional brain networks detected in task-free (“resting-state”) functional magnetic
resonance imaging (fMRI) have a small-world architecture that reflects a robust functional …

Subjective cognitive decline (SCD) is regarded as the first clinical manifestation in the
Alzheimer's disease (AD) continuum. Investigating populations with SCD is important for …

The importance of (micro) vascular contributions to cognitive impairment and dementia
(VCID) in aging cannot be overemphasized, and the pathogenesis and prevention of age …

Objective: To use fMRI to investigate whether hippocampal and entorhinal activation during
learning is altered in the earliest phase of mild cognitive impairment (MCI). Methods: Three …

Age-related cognitive changes often include difficulties in retrieving memories, particularly
those that rely on personal experiences within their temporal and spatial contexts (ie …

Activity and reactivity of the default mode network in the brain was studied using functional
magnetic resonance imaging (fMRI) in 28 nondemented individuals with mild cognitive …