Deciphering the secret of successful aging depends on understanding the patterns and
biological underpinnings of cognitive and behavioral changes throughout adulthood. That …

Aging, hypertension, diabetes, hypoxia/obstructive sleep apnea (OSA), obesity, vitamin
B12/folate deficiency, depression, and traumatic brain injury synergistically promote diverse …

Cross-sectional comparisons have consistently revealed that increased age is associated
with lower levels of cognitive performance, even in the range from 18 to 60 years of age …

Distributions of proton MR‐detected metabolites have been mapped throughout the brain in
a group of normal subjects using a volumetric MR spectroscopic imaging (MRSI) acquisition …

A method for quantitative determination of the glutamate (Glu) concentration in human brain
using PRESS-based single voxel MR spectroscopy (MRS) at 3 T has been developed and …

Several newer magnetic resonance imaging (MRI) techniques are increasingly being
applied to the study of white matter development and pathology across the lifespan. These …

It is generally thought that children learn more efficiently than adults. One way to accomplish
this is to have learning rapidly stabilized such that it is not interfered with by subsequent …

Typically studies of the effects of aging on cognitive-motor performance emphasize changes
in elderly populations. Although some research is directly concerned with when age-related …

Glutamatergic neurotransmission, particularly through the N-methyl-d-aspartate (NMDA)
receptor, has drawn attention for its role in the pathophysiology of schizophrenia. This paper …

BACKGROUND: 1H MR spectroscopy (MRS) can identify metabolite abnormalities in age-
related, neurological diseases. However, there is little information on how metabolites …