Pathological evaluation is the gold standard for identifying processes related to multiple
sclerosis that explain disease manifestations, and for guiding the development of new …

The use of magnetic resonance imaging as a surrogate outcome measure in clinical trials, or
even as a prognosticator in the assessment of the natural evolution, assumes a close …

There has been much recent interest in using magnetic resonance diffusion imaging to
provide information about anatomical connectivity in the brain, by measuring the anisotropic …

Relating brain tissue properties to diffusion tensor imaging (DTI) is limited when an image
voxel contains partial volume of brain tissue with free water, such as cerebrospinal fluid or …

Little is currently known about the alterations in the topological organization of the white
matter (WM) structural networks in patients with multiple sclerosis (MS). In the present study …

Background: Measurements of the T 2 decay curve provide estimates of total water content
and myelin water fraction in white matter in-vivo, which may help in understanding the …

The secondary progressive phase of multiple sclerosis (MS), which is characterised by a
steady accrual of fixed disability after an initial relapsing remitting course, is not clearly …

Diffusion imaging can be used to estimate the routes taken by fiber pathways connecting
different regions of the living brain. This approach has already supplied novel insights into in …

Parkinson's disease involves multiple neurotransmitter systems beyond the classical
dopaminergic circuit, but their influence on structural and functional alterations is not well …

Diffusion tensor imaging (DTI) is an effective means of quantifying parameters of
demyelination and axonal loss. The application of DTI in Multiple Sclerosis (MS) has yielded …