The use of magnetic resonance imaging as a surrogate outcome measure in clinical trials, or
even as a prognosticator in the assessment of the natural evolution, assumes a close …

There has been significant progress in our understanding of the pathology and
pathogenesis of central nervous system inflammatory demyelinating diseases …

Atypical imaging features of multiple sclerosis lesions include size> 2 cm, mass effect,
oedema and/or ring enhancement. This constellation is often referred to as 'tumefactive …

Lesions of Baló's concentric sclerosis are characterized by alternating layers of myelinated
and demyelinated tissue. The reason for concentric demyelination in this variant of multiple …

Multiple sclerosis (MS) is a chronic neurologic disease affecting approximately 1 million
adults worldwide and 300,000 Americans [1]. Early illustrations by Carswell in 1838 and …

Baló's concentric sclerosis is often regarded as a rare variant of multiple sclerosis. Patients
with this disorder present with acute or subacute neurological deterioration, with MRI …

Background: The pathological hallmarks of the multiple sclerosis (MS) lesion consist of focal
demyelination, inflammation, scar formation, and variable axonal destruction. Despite years …

Inflammatory demyelinating diseases of the central nervous system (CNS) occur throughout
the world and are the leading cause of nontraumatic neurological disability in young adults …

We read with great interest the recent article by Paterson et al. entitled 'The emerging
spectrum of COVID-19 neurology: clinical, radiological and laboratory findings'(Paterson et …

Studies in adult patients with multiple sclerosis (MS) suggest significant benefit of early
treatment initiation. However, there are no approved therapies for children and adolescents …