Mechanisms of disease: is osteoporosis the obesity of bone?
CJ Rosen, ML Bouxsein - Nature clinical practice Rheumatology, 2006 - nature.com
Osteoporosis and obesity, two disorders of body composition, are growing in prevalence.
Interestingly, these diseases share several features including a genetic predisposition and a …
Interestingly, these diseases share several features including a genetic predisposition and a …
[HTML][HTML] Fatty infiltration of skeletal muscle: mechanisms and comparisons with bone marrow adiposity
MW Hamrick, ME McGee-Lawrence… - Frontiers in …, 2016 - frontiersin.org
Skeletal muscle and bone share common embryological origins from mesodermal cell
populations and also display common growth trajectories early in life. Moreover, muscle and …
populations and also display common growth trajectories early in life. Moreover, muscle and …
Pathobiology of Modic changes
Purpose Low back pain (LBP) is the most disabling condition worldwide. Although LBP
relates to different spinal pathologies, vertebral bone marrow lesions visualized as Modic …
relates to different spinal pathologies, vertebral bone marrow lesions visualized as Modic …
[HTML][HTML] Obesity and bone health: a complex relationship
A Piñar-Gutierrez, C García-Fontana… - International journal of …, 2022 - mdpi.com
Recent scientific evidence has shown an increased risk of fractures in patients with obesity,
especially in those with a higher visceral adipose tissue content. This contradicts the old …
especially in those with a higher visceral adipose tissue content. This contradicts the old …
Marrow fat and bone—new perspectives
PK Fazeli, MC Horowitz, OA MacDougald… - The Journal of …, 2013 - academic.oup.com
Context: There is growing interest in the relationship between bone mineral density, bone
strength, and fat depots. Marrow adipose tissue, a well-established component of the …
strength, and fat depots. Marrow adipose tissue, a well-established component of the …
Clinical implications of bone marrow adiposity
AG Veldhuis‐Vlug, CJ Rosen - Journal of internal medicine, 2018 - Wiley Online Library
Marrow adipocytes, collectively termed marrow adipose tissue (MAT), reside in the bone
marrow in close contact to bone cells and haematopoietic cells. Marrow adipocytes arise …
marrow in close contact to bone cells and haematopoietic cells. Marrow adipocytes arise …
Bone marrow fat composition as a novel imaging biomarker in postmenopausal women with prevalent fragility fractures
The goal of this magnetic resonance (MR) imaging study was to quantify vertebral bone
marrow fat content and composition in diabetic and nondiabetic postmenopausal women …
marrow fat content and composition in diabetic and nondiabetic postmenopausal women …
Osteoporosis is associated with increased marrow fat content and decreased marrow fat unsaturation: a proton MR spectroscopy study
DKW Yeung, JF Griffith, GE Antonio… - Journal of Magnetic …, 2005 - Wiley Online Library
Purpose To use proton magnetic resonance spectroscopy (1H‐MRS) to evaluate vertebral
marrow fat, and to determine whether bone density correlates with fat content and fat …
marrow fat, and to determine whether bone density correlates with fat content and fat …
Bone health after bariatric surgery
C Gagnon, AL Schafer - Journal of Bone and Mineral Research …, 2018 - academic.oup.com
Bariatric surgery results in long term weight loss and improvement or resolution in obesity
related comorbidities. However, mounting evidence indicates that it adversely affects bone …
related comorbidities. However, mounting evidence indicates that it adversely affects bone …
Vertebral bone mineral density, marrow perfusion, and fat content in healthy men and men with osteoporosis: dynamic contrast-enhanced MR imaging and MR …
JF Griffith, DKW Yeung, GE Antonio, FKH Lee… - Radiology, 2005 - pubs.rsna.org
PURPOSE: To prospectively use hydrogen 1 (1H) magnetic resonance (MR) spectroscopy
and dynamic contrast material–enhanced MR imaging to measure vertebral body marrow fat …
and dynamic contrast material–enhanced MR imaging to measure vertebral body marrow fat …