Mechanisms of disease: is osteoporosis the obesity of bone?

CJ Rosen, ML Bouxsein - Nature clinical practice Rheumatology, 2006 - nature.com
Osteoporosis and obesity, two disorders of body composition, are growing in prevalence.
Interestingly, these diseases share several features including a genetic predisposition and a …

[HTML][HTML] Fatty infiltration of skeletal muscle: mechanisms and comparisons with bone marrow adiposity

MW Hamrick, ME McGee-Lawrence… - Frontiers in …, 2016 - frontiersin.org
Skeletal muscle and bone share common embryological origins from mesodermal cell
populations and also display common growth trajectories early in life. Moreover, muscle and …

Pathobiology of Modic changes

S Dudli, AJ Fields, D Samartzis, J Karppinen… - European Spine …, 2016 - Springer
Purpose Low back pain (LBP) is the most disabling condition worldwide. Although LBP
relates to different spinal pathologies, vertebral bone marrow lesions visualized as Modic …

[HTML][HTML] Obesity and bone health: a complex relationship

A Piñar-Gutierrez, C García-Fontana… - International journal of …, 2022 - mdpi.com
Recent scientific evidence has shown an increased risk of fractures in patients with obesity,
especially in those with a higher visceral adipose tissue content. This contradicts the old …

Marrow fat and bone—new perspectives

PK Fazeli, MC Horowitz, OA MacDougald… - The Journal of …, 2013 - academic.oup.com
Context: There is growing interest in the relationship between bone mineral density, bone
strength, and fat depots. Marrow adipose tissue, a well-established component of the …

Clinical implications of bone marrow adiposity

AG Veldhuis‐Vlug, CJ Rosen - Journal of internal medicine, 2018 - Wiley Online Library
Marrow adipocytes, collectively termed marrow adipose tissue (MAT), reside in the bone
marrow in close contact to bone cells and haematopoietic cells. Marrow adipocytes arise …

Bone marrow fat composition as a novel imaging biomarker in postmenopausal women with prevalent fragility fractures

JM Patsch, X Li, T Baum, SP Yap… - Journal of bone and …, 2013 - academic.oup.com
The goal of this magnetic resonance (MR) imaging study was to quantify vertebral bone
marrow fat content and composition in diabetic and nondiabetic postmenopausal women …

Osteoporosis is associated with increased marrow fat content and decreased marrow fat unsaturation: a proton MR spectroscopy study

DKW Yeung, JF Griffith, GE Antonio… - Journal of Magnetic …, 2005 - Wiley Online Library
Purpose To use proton magnetic resonance spectroscopy (1H‐MRS) to evaluate vertebral
marrow fat, and to determine whether bone density correlates with fat content and fat …

Bone health after bariatric surgery

C Gagnon, AL Schafer - Journal of Bone and Mineral Research …, 2018 - academic.oup.com
Bariatric surgery results in long term weight loss and improvement or resolution in obesity
related comorbidities. However, mounting evidence indicates that it adversely affects bone …

Vertebral bone mineral density, marrow perfusion, and fat content in healthy men and men with osteoporosis: dynamic contrast-enhanced MR imaging and MR …

JF Griffith, DKW Yeung, GE Antonio, FKH Lee… - Radiology, 2005 - pubs.rsna.org
PURPOSE: To prospectively use hydrogen 1 (1H) magnetic resonance (MR) spectroscopy
and dynamic contrast material–enhanced MR imaging to measure vertebral body marrow fat …