No single animal model is able to encompass all of the variables known to affect human
ischemic stroke. This review highlights the major strengths and weaknesses of the most …

Computed tomography (CT) is an established tool for the diagnosis of ischemic or
hemorrhagic stroke. Nonenhanced CT can help exclude hemorrhage and detect “early …

BACKGROUND AND PURPOSE: Dynamic perfusion CT (PCT) with deconvolution produces
maps of time-to-peak (TTP), mean transit time (MTT), regional cerebral blood flow (rCBF) …

BACKGROUND AND PURPOSE: Numerous parameters are involved in dynamic perfusion
CT (PCT). We assessed the influence of the temporal sampling rate and the volume of …

Despite the discovery of several promising neuroprotective therapies in rodent models of
stroke, no therapy other than the fibrinolytics has been found to be effective in human clinical …

The concept of magnetic resonance perfusion-diffusion mismatch (PDM) provides a practical
and approximate measure of the tissue at risk and has been increasingly applied for the …

Animal models are extensively used to evaluate the in vivo functionality of novel drug
delivery systems (DDS). However, many variations likely exist in vivo between the animals …

Background Perfusion CT is able to outline blood perfusion changes in a tissue. Thus, in
lesions of the tissues of the pancreas, this offers to increase the accuracy of CT diagnosis. In …

To further investigate and improve upon current stroke models in nonhuman primates, infarct
size, neurologic function and survival were evaluated in two endovascular ischemic models …

Stroke is the third leading cause of mortality and carries the greatest socioeconomic burden
of disease in North America. Despite several promising therapies discovered in the …