Acute ischemic stroke (AIS) is the fourth leading cause of death and the leading cause of
adult disability in the USA. AIS most commonly occurs when a blood vessel is obstructed …

Background and Purpose—Because of the risk of hemorrhage, especially in the brain,
thrombolytic therapy with intravenous alteplase is restricted by guidelines, and only a small …

Increased red blood cell distribution width (RDW), which is a marker of anisocytosis, is
associated with mortality and cardiovascular events in the general population and in …

Background and Purpose—Recanalization rates after the intravenous (IV) recombinant
tissue plasminogen activator (rt-PA) treatment have been poorly studied in acute stroke …

Background: Stroke is one of the major challenges to health and the reason for increasing
disability-adjusted life years. Despite tremendous progress in preclinical studies, none of the …

Objective Intracerebral hemorrhage (ICH) refers to predominant, sporadic, and non-
traumatic bleeding in the brain parenchyma. The PI3K/AKT/mTOR signaling pathway is an …

Background We aimed to determine whether bridging provides additional benefits over
primary stentriever-based endovascular reperfusion (SER) in patients with proximal middle …

Background and Purpose—The optimal approach to recanalization in acute ischemic stroke
is unknown. We performed a literature review and meta-analysis comparing the relative …

PI3K/AKT/mTOR (phosphoinositide 3-kinase/protein kinase B/mammalian target of
rapamycin) signaling pathway is an important signal transduction pathway mediated by …

Background and Purpose—Intracranial mechanical thrombectomy is a therapeutic option for
acute ischemic stroke patients failing intravenous tissue plasminogen activator (IV tPA). We …