The role of neuroimaging in patients with brain tumors is no longer simply to evaluate
structural abnormality and identify tumor-related complications. By transitioning from a …

The high metabolic rate required for tumor growth often leads to hypoxia in poorly-perfused
regions. Hypoxia activates a complex gene expression program, mediated by hypoxia …

Localized proton magnetic resonance spectroscopy (MRS) of the human brain, first reported
more than 20 years ago, 1–3 is a mature methodology that is used clinically in many medical …

The imaging and clinical management of patients with brain tumor continue to evolve over
time and now heavily rely on physiologic imaging in addition to high-resolution structural …

Chemical inhibitors of histone deacetylase (HDAC) activity are used as experimental tools to
induce histone hyperacetylation and deregulate gene transcription, but it is not known …

Magnetic resonance spectroscopic imaging (MRSI) offers considerable promise for
monitoring metabolic alterations associated with disease or injury; however, to date, these …

▪ Abstract Magnetic resonance spectroscopy (MRS) has been used for more than two
decades to interrogate metabolite distributions in living cells and tissues. Techniques have …

In order to compare in vivo metabolism between malignant gliomas and normal brain, 13C
magnetic resonance (MR) spectroscopic imaging data were acquired from rats with human …

Introduction Diffusion-weighted imaging (DWI), perfusion-weighted imaging (PWI) and MR
spectroscopy (MRS) provide useful data for tumor evaluation. To assess the contribution of …

This article is intended to provide clinical neurologists with an overview of the major
techniques of advanced MRI of brain tumor: diffusion-weighted imaging, perfusion-weighted …