The advent of high-throughput sequencing has facilitated genotype-phenotype correlations
in congenital diseases. This has provided molecular diagnosis and benefited patient …

OBJECTIVE. Herpesviridae are a family of DNA viruses remarkable for their ability to both
promote acute infection and enter a latent phase with potential of reactivation. Herpes …

Background—Cerebral arteriopathies, including an idiopathic focal cerebral arteriopathy of
childhood (FCA), are common in children with arterial ischemic stroke and strongly …

Background—Epidemiological studies demonstrate that childhood infections, including
varicella zoster virus, are associated with an increased risk of arterial ischemic stroke (AIS) …

Understanding the vascular injury pathway is crucial to developing rational strategies for
secondary stroke prevention in children. The multicenter Vascular Effects of Infection in …

Background Pediatric stroke is a distinct clinical entity as compared with that in adults due to
its unique and diverse set of etiologies. Furthermore, the role and application of diagnostic …

Purpose Ras-related C3 botulinum toxin substrate 2 (RAC2) acts as a molecular switch and
has crucial roles in cell signaling and actin dynamics. A broad spectrum of genetic RAC2 …

X‐linked lymphoproliferative disease (XLP) is an immunodeficiency caused by defects in the
adaptor molecule SAP. The manifestations of XLP generally occur following Epstein–Barr …

Stroke is as common as brain tumor in children. The etiology of childhood arterial ischemic
stroke (AIS) appears to be multifactorial, resulting from the interaction between genetic …

Major infections-sepsis, meningitis, encephalitis-have long been recognized as causes of
pediatric arterial ischemic stroke. However, minor infections may also contribute to the …